Retinal Hyperreflective Foci Are Biomarkers of Ocular Disease: A Scoping Review With Evidence From Humans and Insights From Animal Models

Conclusion: There is an agreement that HRF of less than 30 μm are biomarkers of inflammation in the retina despite having variable intraretinal locations. HRF resulting from the effect of aging can be discerned from AMD based on their quantity and appearance. The results show the importance of HRF a...

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Bibliographic Details
Main Authors: Mohd N. Mat Nor, Colin R. Green, David Squirrell, Monica L. Acosta
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Journal of Ophthalmology
Online Access:http://dx.doi.org/10.1155/joph/9573587
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Summary:Conclusion: There is an agreement that HRF of less than 30 μm are biomarkers of inflammation in the retina despite having variable intraretinal locations. HRF resulting from the effect of aging can be discerned from AMD based on their quantity and appearance. The results show the importance of HRF as a biomarker of ocular disease and confirm that HRF are indicative of an inflammatory eye disorder.
ISSN:2090-0058