Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety
Abstract Despite the high correlation between anxiety and depression, little remains known about the course of each condition when presenting concurrently. This study aimed to identify longitudinal patterns during antidepressant treatment in patients with depression and anxiety, and evaluate related...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | npj Mental Health Research |
| Online Access: | https://doi.org/10.1038/s44184-024-00104-8 |
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| author | Judith Cukor Zhenxing Xu Veer Vekaria Fei Wang Mark Olfson Samprit Banerjee Gregory Simon George Alexopoulos Jyotishman Pathak |
| author_facet | Judith Cukor Zhenxing Xu Veer Vekaria Fei Wang Mark Olfson Samprit Banerjee Gregory Simon George Alexopoulos Jyotishman Pathak |
| author_sort | Judith Cukor |
| collection | DOAJ |
| description | Abstract Despite the high correlation between anxiety and depression, little remains known about the course of each condition when presenting concurrently. This study aimed to identify longitudinal patterns during antidepressant treatment in patients with depression and anxiety, and evaluate related factors associated with these patterns. By analyzing longitudinal self-report Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7) scores that tracked courses of depression and anxiety over a three-month window among the 577 adult participants, six depression and six anxiety trajectory subgroups were computationally derived using group-based trajectory modeling. Three depression subgroups showed symptom improvement, while three showed nonresponses. Similar patterns were observed in the six anxiety subgroups. Multinomial regression was used to associate patient characteristics with trajectory subgroup membership. Compared to patients in the remission group, factors associated with depressive symptom nonresponse included older age and lower depression severity. |
| format | Article |
| id | doaj-art-e4f56f67132646cebbd78f2fa0e91498 |
| institution | DOAJ |
| issn | 2731-4251 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Mental Health Research |
| spelling | doaj-art-e4f56f67132646cebbd78f2fa0e914982025-08-20T02:51:18ZengNature Portfolionpj Mental Health Research2731-42512024-11-01311810.1038/s44184-024-00104-8Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxietyJudith Cukor0Zhenxing Xu1Veer Vekaria2Fei Wang3Mark Olfson4Samprit Banerjee5Gregory Simon6George Alexopoulos7Jyotishman Pathak8Weill Cornell MedicineWeill Cornell MedicineWeill Cornell MedicineWeill Cornell MedicineColumbia UniversityWeill Cornell MedicineKaiser Permanente Washington Health Research InstituteWeill Cornell MedicineWeill Cornell MedicineAbstract Despite the high correlation between anxiety and depression, little remains known about the course of each condition when presenting concurrently. This study aimed to identify longitudinal patterns during antidepressant treatment in patients with depression and anxiety, and evaluate related factors associated with these patterns. By analyzing longitudinal self-report Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7) scores that tracked courses of depression and anxiety over a three-month window among the 577 adult participants, six depression and six anxiety trajectory subgroups were computationally derived using group-based trajectory modeling. Three depression subgroups showed symptom improvement, while three showed nonresponses. Similar patterns were observed in the six anxiety subgroups. Multinomial regression was used to associate patient characteristics with trajectory subgroup membership. Compared to patients in the remission group, factors associated with depressive symptom nonresponse included older age and lower depression severity.https://doi.org/10.1038/s44184-024-00104-8 |
| spellingShingle | Judith Cukor Zhenxing Xu Veer Vekaria Fei Wang Mark Olfson Samprit Banerjee Gregory Simon George Alexopoulos Jyotishman Pathak Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety npj Mental Health Research |
| title | Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety |
| title_full | Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety |
| title_fullStr | Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety |
| title_full_unstemmed | Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety |
| title_short | Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety |
| title_sort | longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety |
| url | https://doi.org/10.1038/s44184-024-00104-8 |
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