Noise-aided logic in an electronic analog of synthetic genetic networks.
We report the experimental verification of noise-enhanced logic behaviour in an electronic analog of a synthetic genetic network, composed of two repressors and two constitutive promoters. We observe good agreement between circuit measurements and numerical prediction, with the circuit allowing for...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076032&type=printable |
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| author | Edward H Hellen Syamal K Dana Jürgen Kurths Eli Kehler Sudeshna Sinha |
| author_facet | Edward H Hellen Syamal K Dana Jürgen Kurths Eli Kehler Sudeshna Sinha |
| author_sort | Edward H Hellen |
| collection | DOAJ |
| description | We report the experimental verification of noise-enhanced logic behaviour in an electronic analog of a synthetic genetic network, composed of two repressors and two constitutive promoters. We observe good agreement between circuit measurements and numerical prediction, with the circuit allowing for robust logic operations in an optimal window of noise. Namely, the input-output characteristics of a logic gate is reproduced faithfully under moderate noise, which is a manifestation of the phenomenon known as Logical Stochastic Resonance. The two dynamical variables in the system yield complementary logic behaviour simultaneously. The system is easily morphed from AND/NAND to OR/NOR logic. |
| format | Article |
| id | doaj-art-e4f2cb4ae8e645049dbaa7254bddb4ec |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e4f2cb4ae8e645049dbaa7254bddb4ec2025-08-20T02:12:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7603210.1371/journal.pone.0076032Noise-aided logic in an electronic analog of synthetic genetic networks.Edward H HellenSyamal K DanaJürgen KurthsEli KehlerSudeshna SinhaWe report the experimental verification of noise-enhanced logic behaviour in an electronic analog of a synthetic genetic network, composed of two repressors and two constitutive promoters. We observe good agreement between circuit measurements and numerical prediction, with the circuit allowing for robust logic operations in an optimal window of noise. Namely, the input-output characteristics of a logic gate is reproduced faithfully under moderate noise, which is a manifestation of the phenomenon known as Logical Stochastic Resonance. The two dynamical variables in the system yield complementary logic behaviour simultaneously. The system is easily morphed from AND/NAND to OR/NOR logic.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076032&type=printable |
| spellingShingle | Edward H Hellen Syamal K Dana Jürgen Kurths Eli Kehler Sudeshna Sinha Noise-aided logic in an electronic analog of synthetic genetic networks. PLoS ONE |
| title | Noise-aided logic in an electronic analog of synthetic genetic networks. |
| title_full | Noise-aided logic in an electronic analog of synthetic genetic networks. |
| title_fullStr | Noise-aided logic in an electronic analog of synthetic genetic networks. |
| title_full_unstemmed | Noise-aided logic in an electronic analog of synthetic genetic networks. |
| title_short | Noise-aided logic in an electronic analog of synthetic genetic networks. |
| title_sort | noise aided logic in an electronic analog of synthetic genetic networks |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076032&type=printable |
| work_keys_str_mv | AT edwardhhellen noiseaidedlogicinanelectronicanalogofsyntheticgeneticnetworks AT syamalkdana noiseaidedlogicinanelectronicanalogofsyntheticgeneticnetworks AT jurgenkurths noiseaidedlogicinanelectronicanalogofsyntheticgeneticnetworks AT elikehler noiseaidedlogicinanelectronicanalogofsyntheticgeneticnetworks AT sudeshnasinha noiseaidedlogicinanelectronicanalogofsyntheticgeneticnetworks |