Role of integrins in wound repair and its periodontal implications
Wound healing in human periodontium is a complex process which involves both cell-cell and cell-matrix interactions. Integrins play a major role in regulation of these cell-cell, cell-matrix interaction. Wound healing involves two major events i.e. re-epithelialization and connective tissue repair....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-05-01
|
| Series: | Journal of Oral Biology and Craniofacial Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426818300058 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850236629296349184 |
|---|---|
| author | Harpal Jakhu Gurveen Gill Amarjot Singh |
| author_facet | Harpal Jakhu Gurveen Gill Amarjot Singh |
| author_sort | Harpal Jakhu |
| collection | DOAJ |
| description | Wound healing in human periodontium is a complex process which involves both cell-cell and cell-matrix interactions. Integrins play a major role in regulation of these cell-cell, cell-matrix interaction. Wound healing involves two major events i.e. re-epithelialization and connective tissue repair. In this concise review, we will discuss the role of integrins in these major events as well as their impIications in periodontal wound repair. Integrins are differentially expressed in both of these major events. In re-epithelialization, keratinocytes express novel integrins receptors αvβ1, α5β1and αvβ6 which are not expressed in normal healthy epithelium. Re-epithelialization also involves interaction of integrins with TGF-β and fibronectin. Similarly, in connective tissue repair, the activation of fibroblast as well as the expression of integrins α5β1 and α3β1 is upregulated. In healthy periodontium, integrin αvβ6 is normally expressed in junctional epithelium which is generally expressed only at wound sites in other parts of the body. The epithelialization at implant surface has not been yet fully explored with respect to interactions among integrins and other extra-cellular matrix molecules. |
| format | Article |
| id | doaj-art-e4f15743b4b84138a45669112235cdc8 |
| institution | OA Journals |
| issn | 2212-4268 |
| language | English |
| publishDate | 2018-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-e4f15743b4b84138a45669112235cdc82025-08-20T02:01:56ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682018-05-018212212510.1016/j.jobcr.2018.01.002Role of integrins in wound repair and its periodontal implicationsHarpal Jakhu0Gurveen Gill1Amarjot Singh2Department of Endodontics, Government Dental College, Amritsar, Punjab, India; Sandalwood Smiles, Private Dental Practice, Brampton, Ontario, CanadaFaculty of Dentistry, McGill Univeristy, Montreal, Quebec, Canada; Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, CanadaFaculty of Dentistry, McGill Univeristy, Montreal, Quebec, Canada; Corresponding author at: Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.Wound healing in human periodontium is a complex process which involves both cell-cell and cell-matrix interactions. Integrins play a major role in regulation of these cell-cell, cell-matrix interaction. Wound healing involves two major events i.e. re-epithelialization and connective tissue repair. In this concise review, we will discuss the role of integrins in these major events as well as their impIications in periodontal wound repair. Integrins are differentially expressed in both of these major events. In re-epithelialization, keratinocytes express novel integrins receptors αvβ1, α5β1and αvβ6 which are not expressed in normal healthy epithelium. Re-epithelialization also involves interaction of integrins with TGF-β and fibronectin. Similarly, in connective tissue repair, the activation of fibroblast as well as the expression of integrins α5β1 and α3β1 is upregulated. In healthy periodontium, integrin αvβ6 is normally expressed in junctional epithelium which is generally expressed only at wound sites in other parts of the body. The epithelialization at implant surface has not been yet fully explored with respect to interactions among integrins and other extra-cellular matrix molecules.http://www.sciencedirect.com/science/article/pii/S2212426818300058IntegrinsWound RepairPeriodontiumKeratinocytesFibroblasts |
| spellingShingle | Harpal Jakhu Gurveen Gill Amarjot Singh Role of integrins in wound repair and its periodontal implications Journal of Oral Biology and Craniofacial Research Integrins Wound Repair Periodontium Keratinocytes Fibroblasts |
| title | Role of integrins in wound repair and its periodontal implications |
| title_full | Role of integrins in wound repair and its periodontal implications |
| title_fullStr | Role of integrins in wound repair and its periodontal implications |
| title_full_unstemmed | Role of integrins in wound repair and its periodontal implications |
| title_short | Role of integrins in wound repair and its periodontal implications |
| title_sort | role of integrins in wound repair and its periodontal implications |
| topic | Integrins Wound Repair Periodontium Keratinocytes Fibroblasts |
| url | http://www.sciencedirect.com/science/article/pii/S2212426818300058 |
| work_keys_str_mv | AT harpaljakhu roleofintegrinsinwoundrepairanditsperiodontalimplications AT gurveengill roleofintegrinsinwoundrepairanditsperiodontalimplications AT amarjotsingh roleofintegrinsinwoundrepairanditsperiodontalimplications |