AN ESTIMATION OF FREQUENCY AND SPECTRUM OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA IN CONDITIONS OF BLOOD CELLS CONTACT WITH NANOSTRUCTURED MATERIALS
In order to evaluate cytogenetic effect of nanocomposite materials used in traumatology and orthopedics an investigation of chromosomal aberration ins in the culture of lymphocytes short-term contacted with artificial material (nanostructured titanium samples of implants bearing bilateral calcium ph...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2013-12-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/327 |
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| _version_ | 1849400205313572864 |
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| author | М. V. Dvornichenko |
| author_facet | М. V. Dvornichenko |
| author_sort | М. V. Dvornichenko |
| collection | DOAJ |
| description | In order to evaluate cytogenetic effect of nanocomposite materials used in traumatology and orthopedics an investigation of chromosomal aberration ins in the culture of lymphocytes short-term contacted with artificial material (nanostructured titanium samples of implants bearing bilateral calcium phosphate coating) in patients with dysplasia of connective tissue (DCT) and osteogenesis imperfecta (OI) has been conducted. A reduction of percent of aberrant cells having single or/and paired chromosomal breaks as compared with spontaneous mutagenesis (without model samples) was revealed under introduced biocompatible composites into blood cell cultures of patients with DCT or OI. Analysis of frequency and spectrum of chromosomal aberrations in blood cells can be considered as potential prognostic criterion and a predictor of implant’s efficacy in the surgical treatment of DCT and OI complications. |
| format | Article |
| id | doaj-art-e4f11b465714457192bff78ddca817bc |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-e4f11b465714457192bff78ddca817bc2025-08-20T03:38:08ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842013-12-0112617518110.20538/1682-0363-2013-6-175-181323AN ESTIMATION OF FREQUENCY AND SPECTRUM OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA IN CONDITIONS OF BLOOD CELLS CONTACT WITH NANOSTRUCTURED MATERIALSМ. V. Dvornichenko0Scientific Educational Center “Biocompatible Materials and Bioengineering” at Tomsk Polytechnic University, Siberian State Medical University, Institute of Strength Physics and Materials Science of Siberian Branch of Russia Academy of Sciences, TomskIn order to evaluate cytogenetic effect of nanocomposite materials used in traumatology and orthopedics an investigation of chromosomal aberration ins in the culture of lymphocytes short-term contacted with artificial material (nanostructured titanium samples of implants bearing bilateral calcium phosphate coating) in patients with dysplasia of connective tissue (DCT) and osteogenesis imperfecta (OI) has been conducted. A reduction of percent of aberrant cells having single or/and paired chromosomal breaks as compared with spontaneous mutagenesis (without model samples) was revealed under introduced biocompatible composites into blood cell cultures of patients with DCT or OI. Analysis of frequency and spectrum of chromosomal aberrations in blood cells can be considered as potential prognostic criterion and a predictor of implant’s efficacy in the surgical treatment of DCT and OI complications.https://bulletin.ssmu.ru/jour/article/view/327single and paired chromosomal breaks, lymphocytes culture, in vitro, dysplasia of con-nective tissue, nanostructured titanium, calcium phosphate coating |
| spellingShingle | М. V. Dvornichenko AN ESTIMATION OF FREQUENCY AND SPECTRUM OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA IN CONDITIONS OF BLOOD CELLS CONTACT WITH NANOSTRUCTURED MATERIALS Бюллетень сибирской медицины single and paired chromosomal breaks, lymphocytes culture, in vitro, dysplasia of con-nective tissue, nanostructured titanium, calcium phosphate coating |
| title | AN ESTIMATION OF FREQUENCY AND SPECTRUM OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA IN CONDITIONS OF BLOOD CELLS CONTACT WITH NANOSTRUCTURED MATERIALS |
| title_full | AN ESTIMATION OF FREQUENCY AND SPECTRUM OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA IN CONDITIONS OF BLOOD CELLS CONTACT WITH NANOSTRUCTURED MATERIALS |
| title_fullStr | AN ESTIMATION OF FREQUENCY AND SPECTRUM OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA IN CONDITIONS OF BLOOD CELLS CONTACT WITH NANOSTRUCTURED MATERIALS |
| title_full_unstemmed | AN ESTIMATION OF FREQUENCY AND SPECTRUM OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA IN CONDITIONS OF BLOOD CELLS CONTACT WITH NANOSTRUCTURED MATERIALS |
| title_short | AN ESTIMATION OF FREQUENCY AND SPECTRUM OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA IN CONDITIONS OF BLOOD CELLS CONTACT WITH NANOSTRUCTURED MATERIALS |
| title_sort | estimation of frequency and spectrum of chromosomal aberrations in patients with connective tissue dysplasia in conditions of blood cells contact with nanostructured materials |
| topic | single and paired chromosomal breaks, lymphocytes culture, in vitro, dysplasia of con-nective tissue, nanostructured titanium, calcium phosphate coating |
| url | https://bulletin.ssmu.ru/jour/article/view/327 |
| work_keys_str_mv | AT mvdvornichenko anestimationoffrequencyandspectrumofchromosomalaberrationsinpatientswithconnectivetissuedysplasiainconditionsofbloodcellscontactwithnanostructuredmaterials AT mvdvornichenko estimationoffrequencyandspectrumofchromosomalaberrationsinpatientswithconnectivetissuedysplasiainconditionsofbloodcellscontactwithnanostructuredmaterials |