Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1
The budding yeast Candida albicans is one of the most significant fungal pathogens worldwide. It proliferates in two distinct cell types: blastopores and filaments. Only cells that are able to transform from one cell type into the other are virulent in mouse disease models. Programmed cell death is...
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| Language: | English |
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Shared Science Publishers OG
2016-04-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/filamentation-protects-candida-albicans-from-amphotericin-b-induced-programmed-cell-death-via-a-mechanism-involving-the-yeast-metacaspase-mca1/ |
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| author | David J. Laprade Melissa S. Brown Morgan L. McCarthy James J. Ritch Nicanor Austriaco |
| author_facet | David J. Laprade Melissa S. Brown Morgan L. McCarthy James J. Ritch Nicanor Austriaco |
| author_sort | David J. Laprade |
| collection | DOAJ |
| description | The budding yeast Candida albicans is one of the most significant fungal pathogens worldwide. It proliferates in two distinct cell types: blastopores and filaments. Only cells that are able to transform from one cell type into the other are virulent in mouse disease models. Programmed cell death is a controlled form of cell suicide that occurs when C. albicans cells are exposed to fungicidal drugs like amphotericin B and caspofungin, and to other stressful conditions. We now provide evidence that suggests that programmed cell death is cell-type specific in yeast: Filamentous C. albicans cells are more resistant to amphotericin B- and caspofungin-induced programmed cell death than their blastospore counterparts. Finally, our genetic data suggests that this phenomenon is mediated by a protective mechanism involving the yeast metacaspase, MCA1. |
| format | Article |
| id | doaj-art-e4eec83c706941b681fa60b34733292f |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2016-04-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-e4eec83c706941b681fa60b34733292f2025-08-20T02:52:37ZengShared Science Publishers OGMicrobial Cell2311-26382016-04-013728529210.15698/mic2016.07.512Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1David J. Laprade0Melissa S. Brown1Morgan L. McCarthy2James J. Ritch3Nicanor Austriaco4Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.The budding yeast Candida albicans is one of the most significant fungal pathogens worldwide. It proliferates in two distinct cell types: blastopores and filaments. Only cells that are able to transform from one cell type into the other are virulent in mouse disease models. Programmed cell death is a controlled form of cell suicide that occurs when C. albicans cells are exposed to fungicidal drugs like amphotericin B and caspofungin, and to other stressful conditions. We now provide evidence that suggests that programmed cell death is cell-type specific in yeast: Filamentous C. albicans cells are more resistant to amphotericin B- and caspofungin-induced programmed cell death than their blastospore counterparts. Finally, our genetic data suggests that this phenomenon is mediated by a protective mechanism involving the yeast metacaspase, MCA1.http://microbialcell.com/researcharticles/filamentation-protects-candida-albicans-from-amphotericin-b-induced-programmed-cell-death-via-a-mechanism-involving-the-yeast-metacaspase-mca1/Candida albicansamphotericin Bcaspofungin MCA1programmed cell deathfilamentation |
| spellingShingle | David J. Laprade Melissa S. Brown Morgan L. McCarthy James J. Ritch Nicanor Austriaco Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1 Microbial Cell Candida albicans amphotericin B caspofungin MCA1 programmed cell death filamentation |
| title | Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1 |
| title_full | Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1 |
| title_fullStr | Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1 |
| title_full_unstemmed | Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1 |
| title_short | Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1 |
| title_sort | filamentation protects candida albicans from amphotericin b induced programmed cell death via a mechanism involving the yeast metacaspase mca1 |
| topic | Candida albicans amphotericin B caspofungin MCA1 programmed cell death filamentation |
| url | http://microbialcell.com/researcharticles/filamentation-protects-candida-albicans-from-amphotericin-b-induced-programmed-cell-death-via-a-mechanism-involving-the-yeast-metacaspase-mca1/ |
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