Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation

Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation

Objective: To investigate the feasibility of constructing cartilaginous organoids (CORGs) using cartilage extracellular matrix microcarriers (CEMMs), evaluate their ectopic chondrogenic potential, and analyze their impact on in situ repair and regeneration of knee cartilage in SD rats. Methods: Cart...

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Main Authors: Hongyu Jiang, Wei Liu, Jiajie Chen, Yue Tian, Zhibo Jia, Yanbin Wu, Yanjun Guan, Leijia Chen, Wenjing Xu, Haoye Meng, Yingjie Xiong, Jianting Ye, Cheng Huang, Ruichao He, Sice Wang, Yufei Ding, Wei Fan, Yunkang Yang, Jiang Peng, Aiyuan Wang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Orthopaedic Translation
Subjects:
Cartilaginous organoids
Cartilage extracellular matrix microcarriers
Cartilage regeneration
Immune regulation.
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X25000828
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