LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN
Local and system influence the Repleri gel implants on the base of hyaluronic acid used to correct age-related changes in skin has been studied. Human stromal stem cells with CD44 membrane receptor to hyaluronic acid migrates in vitro into gel structure and maturates morphologically in fibroblast-li...
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| Format: | Article |
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Siberian State Medical University (Tomsk)
2013-02-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/39 |
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| author | I. A. Khlusov V. A. Igumnov D. I. Choukhnova O. L. Mytasova K. V. Zaitsev N. G. Abdulkina A. A. Zaitsev L. Yu. Kolesova |
| author_facet | I. A. Khlusov V. A. Igumnov D. I. Choukhnova O. L. Mytasova K. V. Zaitsev N. G. Abdulkina A. A. Zaitsev L. Yu. Kolesova |
| author_sort | I. A. Khlusov |
| collection | DOAJ |
| description | Local and system influence the Repleri gel implants on the base of hyaluronic acid used to correct age-related changes in skin has been studied. Human stromal stem cells with CD44 membrane receptor to hyaluronic acid migrates in vitro into gel structure and maturates morphologically in fibroblast-like forms stained positively with acid phosphatase. Repleri gels implantation in the group of women with local and system age-related changes in homeostasis has positive local effect connected with full deletion of nasolabial fold in facial skin. Repleri gels injection has been decreasing during 1 year the system indices of real biological age as compared with chronological (passport) one. Lipoproteins and aspartate aminotransferase concentrations diminished statistically in women blood. An effect revealed may be considered as potential way of anti-age therapy of not only skin but parenchymal organs. At the same time, a long-term control of homeostasis distant indices in women with serious changes in parenchymal organs is necessary after local Repleri gels injection because of organism’s hormonal reactions. |
| format | Article |
| id | doaj-art-e4ec241fdffb421f8d1e31fa125538dd |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2013-02-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-e4ec241fdffb421f8d1e31fa125538dd2025-08-20T03:21:43ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842013-02-01121616810.20538/1682-0363-2013-1-61-6839LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKINI. A. Khlusov0V. A. Igumnov1D. I. Choukhnova2O. L. Mytasova3K. V. Zaitsev4N. G. Abdulkina5A. A. Zaitsev6L. Yu. Kolesova7Scientific Educational Center “Biocompatible Materials and Bioengineering”, Chair of Morphology and General Pathology of Siberian State Medical University; Bioconstructor-S Ltd., TomskSiberian Polyclinics Ltd.Siberian Polyclinics Ltd.Siberian Polyclinics Ltd.Laboratory of Study of Mechanisms of Physical factors Action, Tomsk SRI of Balneology and Physiotherapy, TomskTomsk SRI of Balneology and Physiotherapy, TomskTomsk SRI of Balneology and Physiotherapy, TomskNovoNexus Ltd., MoscowLocal and system influence the Repleri gel implants on the base of hyaluronic acid used to correct age-related changes in skin has been studied. Human stromal stem cells with CD44 membrane receptor to hyaluronic acid migrates in vitro into gel structure and maturates morphologically in fibroblast-like forms stained positively with acid phosphatase. Repleri gels implantation in the group of women with local and system age-related changes in homeostasis has positive local effect connected with full deletion of nasolabial fold in facial skin. Repleri gels injection has been decreasing during 1 year the system indices of real biological age as compared with chronological (passport) one. Lipoproteins and aspartate aminotransferase concentrations diminished statistically in women blood. An effect revealed may be considered as potential way of anti-age therapy of not only skin but parenchymal organs. At the same time, a long-term control of homeostasis distant indices in women with serious changes in parenchymal organs is necessary after local Repleri gels injection because of organism’s hormonal reactions.https://bulletin.ssmu.ru/jour/article/view/39stromal stem cellsin vitroacid phosphatasewomennasolabial foldbloodbiochemis-tryhormones |
| spellingShingle | I. A. Khlusov V. A. Igumnov D. I. Choukhnova O. L. Mytasova K. V. Zaitsev N. G. Abdulkina A. A. Zaitsev L. Yu. Kolesova LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN Бюллетень сибирской медицины stromal stem cells in vitro acid phosphatase women nasolabial fold blood biochemis-try hormones |
| title | LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN |
| title_full | LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN |
| title_fullStr | LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN |
| title_full_unstemmed | LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN |
| title_short | LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN |
| title_sort | local and system effects of hyaluronic acid implants in conditions of corrections of age related changes in skin |
| topic | stromal stem cells in vitro acid phosphatase women nasolabial fold blood biochemis-try hormones |
| url | https://bulletin.ssmu.ru/jour/article/view/39 |
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