Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice
The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct siz...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/373872 |
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| author | Ya-Xuan Sun Ting Liu Xue-Ling Dai Ya-Bo Li Yu-Yao Li Hua Zhang Li-Zhe An |
| author_facet | Ya-Xuan Sun Ting Liu Xue-Ling Dai Ya-Bo Li Yu-Yao Li Hua Zhang Li-Zhe An |
| author_sort | Ya-Xuan Sun |
| collection | DOAJ |
| description | The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct size, MDA and carbonyl contents, and GSH/GSSG ratio compared with the model control group. After being treated by Chorispora bungeana, SOD, CAT, and GSH-Px activities remarkably increased. Chorispora bungeana treatment also improved 8-OHdG expression and cell apoptosis. Our findings indicated that the water extract of Chorispora bungeana possesses neuroprotective effect which is most likely achieved by antioxidant and antiapoptotic activities. |
| format | Article |
| id | doaj-art-e4e71383e3e34903b88697d8e7794298 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e4e71383e3e34903b88697d8e77942982025-08-20T03:26:25ZengWileyJournal of Chemistry2090-90632090-90712014-01-01201410.1155/2014/373872373872Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in MiceYa-Xuan Sun0Ting Liu1Xue-Ling Dai2Ya-Bo Li3Yu-Yao Li4Hua Zhang5Li-Zhe An6Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaSchool of Pharmacy, Shihezi University, Shihezi 832002, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaKey Laboratory of Arid and Grassland Agroecology (Ministry Education), School of Life Sciences, Lanzhou University, Lanzhou 730000, ChinaKey Laboratory of Arid and Grassland Agroecology (Ministry Education), School of Life Sciences, Lanzhou University, Lanzhou 730000, ChinaKey Laboratory of Arid and Grassland Agroecology (Ministry Education), School of Life Sciences, Lanzhou University, Lanzhou 730000, ChinaKey Laboratory of Arid and Grassland Agroecology (Ministry Education), School of Life Sciences, Lanzhou University, Lanzhou 730000, ChinaThe purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct size, MDA and carbonyl contents, and GSH/GSSG ratio compared with the model control group. After being treated by Chorispora bungeana, SOD, CAT, and GSH-Px activities remarkably increased. Chorispora bungeana treatment also improved 8-OHdG expression and cell apoptosis. Our findings indicated that the water extract of Chorispora bungeana possesses neuroprotective effect which is most likely achieved by antioxidant and antiapoptotic activities.http://dx.doi.org/10.1155/2014/373872 |
| spellingShingle | Ya-Xuan Sun Ting Liu Xue-Ling Dai Ya-Bo Li Yu-Yao Li Hua Zhang Li-Zhe An Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice Journal of Chemistry |
| title | Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice |
| title_full | Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice |
| title_fullStr | Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice |
| title_full_unstemmed | Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice |
| title_short | Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice |
| title_sort | neuroprotective activity of water soluble extract from chorispora bungeana against focal cerebral ischemic reperfusion injury in mice |
| url | http://dx.doi.org/10.1155/2014/373872 |
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