Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.)
Abstract Elsholtzia splendens, a perennial herb native to East Asia, is valued for its ornamental and medicinal uses, particularly in treating inflammatory and febrile conditions. Recent studies have highlighted its antibacterial, anti-inflammatory, antidepressant, antithrombotic, and lipid-lowering...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-025-05214-2 |
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| author | Sung Jin Moon Sae Hyun Lee Woo Hyun Sim Han Suk Choi Ju Seok Lee Sangrea Shim |
| author_facet | Sung Jin Moon Sae Hyun Lee Woo Hyun Sim Han Suk Choi Ju Seok Lee Sangrea Shim |
| author_sort | Sung Jin Moon |
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| description | Abstract Elsholtzia splendens, a perennial herb native to East Asia, is valued for its ornamental and medicinal uses, particularly in treating inflammatory and febrile conditions. Recent studies have highlighted its antibacterial, anti-inflammatory, antidepressant, antithrombotic, and lipid-lowering properties of its compounds. Additionally, E. splendens shows potential for phytoremediation owing to its ability to hyperaccumulate copper (Cu), lead (Pb), zinc (Zn), and cadmium (Cd). However, its role in remediation conflicts with its medicinal use because of the risk of heavy metal accumulation. Genome sequencing will be key to boosting beneficial compound production and reducing heavy metal risks. In this study, we generated a high-resolution, haplotype-resolved, chromosome-scale genome sequence of E. splendens using PacBio Revio long-read, Illumina short-read, and Hi-C sequencing technologies. The haplotype genome assemblies, spanned 275.4 and 265.0 Mbp with a scaffold N50 of 33.9 and 33.8 Mbp for haplotype 1 and 2, respectively. This assembly provides valuable insights into medicinal compound biosynthesis and supports genetic conservation efforts, facilitating future genetic and biotechnological applications of E. splendens for medicinal and ecological uses. |
| format | Article |
| id | doaj-art-e4e4e04689044c798939be19c6b6cd15 |
| institution | OA Journals |
| issn | 2052-4463 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Data |
| spelling | doaj-art-e4e4e04689044c798939be19c6b6cd152025-08-20T02:34:06ZengNature PortfolioScientific Data2052-44632025-05-0112111010.1038/s41597-025-05214-2Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.)Sung Jin Moon0Sae Hyun Lee1Woo Hyun Sim2Han Suk Choi3Ju Seok Lee4Sangrea Shim5Department of Forest Resources, College of Forest and Environmental Sciences, Kangwon National UniversityDepartment of Agriculture, Forestry and Bioresources, College of Agriculture & Life Sciences, Seoul National UniversityDepartment of Forest Resources, College of Forest and Environmental Sciences, Kangwon National UniversityDepartment of Forest Resources, College of Forest and Environmental Sciences, Kangwon National UniversityBio-evaluation Center, Korea Research Institute of Bioscience and BiotechnologyDepartment of Forest Resources, College of Forest and Environmental Sciences, Kangwon National UniversityAbstract Elsholtzia splendens, a perennial herb native to East Asia, is valued for its ornamental and medicinal uses, particularly in treating inflammatory and febrile conditions. Recent studies have highlighted its antibacterial, anti-inflammatory, antidepressant, antithrombotic, and lipid-lowering properties of its compounds. Additionally, E. splendens shows potential for phytoremediation owing to its ability to hyperaccumulate copper (Cu), lead (Pb), zinc (Zn), and cadmium (Cd). However, its role in remediation conflicts with its medicinal use because of the risk of heavy metal accumulation. Genome sequencing will be key to boosting beneficial compound production and reducing heavy metal risks. In this study, we generated a high-resolution, haplotype-resolved, chromosome-scale genome sequence of E. splendens using PacBio Revio long-read, Illumina short-read, and Hi-C sequencing technologies. The haplotype genome assemblies, spanned 275.4 and 265.0 Mbp with a scaffold N50 of 33.9 and 33.8 Mbp for haplotype 1 and 2, respectively. This assembly provides valuable insights into medicinal compound biosynthesis and supports genetic conservation efforts, facilitating future genetic and biotechnological applications of E. splendens for medicinal and ecological uses.https://doi.org/10.1038/s41597-025-05214-2 |
| spellingShingle | Sung Jin Moon Sae Hyun Lee Woo Hyun Sim Han Suk Choi Ju Seok Lee Sangrea Shim Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.) Scientific Data |
| title | Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.) |
| title_full | Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.) |
| title_fullStr | Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.) |
| title_full_unstemmed | Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.) |
| title_short | Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.) |
| title_sort | haplotype resolved chromosome level genome sequence of elsholtzia splendens nakai ex f maek |
| url | https://doi.org/10.1038/s41597-025-05214-2 |
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