Past Cigarette Smoking Is More Common among Those with Cholinergic Than Noncholinergic Dementias
Background. Patients with progressive dementing disorders associated with cortical cholinergic dysfunction gradually develop cholinergic deficits many years before symptom onset and may begin to smoke cigarettes during midlife as a form of self-medication. The aim of this study was to compare self-r...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2014/423602 |
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| author | Kyle Dalrymple Erin K. Saito Natalie Diaz Julia Morrow Beau Nakamoto Aaron M. McMurtray |
| author_facet | Kyle Dalrymple Erin K. Saito Natalie Diaz Julia Morrow Beau Nakamoto Aaron M. McMurtray |
| author_sort | Kyle Dalrymple |
| collection | DOAJ |
| description | Background. Patients with progressive dementing disorders associated with cortical cholinergic dysfunction gradually develop cholinergic deficits many years before symptom onset and may begin to smoke cigarettes during midlife as a form of self-medication. The aim of this study was to compare self-reported past smoking rates between those with and without cholinergic dementias, to determine if those who developed cholinergic dementias were more likely to smoke during midlife than those who did not. Methods. Retrospective cross-sectional study of past smoking status among patients treated at an outpatient clinic during a three-year period. Results. A total of 440 patients were evaluated during the study period, including 224 with cholinergic dementias and 216 with noncholinergic dementias and controls. Past smoking rates were greater among those with cholinergic dementias compared to those without cholinergic dementias (43.92% versus 26.96%, P=0.012). Additionally, smokers with cholinergic dementias reported significantly greater mean pack-years of smoking (P=0.038). Conclusions. Greater midlife smoking rates and greater pack-years of smoking were associated with cholinergic dementias. These results suggest midlife smoking may be an early indicator for those developing brain cholinergic deficits related to progressive dementing disorders and support initiating treatment prior to symptom onset in cholinergic dementias. |
| format | Article |
| id | doaj-art-e4e42a29883f4b6db4530aef9645e110 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Neurology Research International |
| spelling | doaj-art-e4e42a29883f4b6db4530aef9645e1102025-02-03T01:20:04ZengWileyNeurology Research International2090-18522090-18602014-01-01201410.1155/2014/423602423602Past Cigarette Smoking Is More Common among Those with Cholinergic Than Noncholinergic DementiasKyle Dalrymple0Erin K. Saito1Natalie Diaz2Julia Morrow3Beau Nakamoto4Aaron M. McMurtray5Pitzer College, Claremont, CA 91711, USANeurology Division, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USANeurology Division, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USANeurology Department, Harbor-UCLA Medical Center, Building N-25, 1000 West Carson Street, Torrance, CA 90509, USANeurology Department, Straub Hospital and Clinics, Honolulu, HI 96813, USANeurology Division, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USABackground. Patients with progressive dementing disorders associated with cortical cholinergic dysfunction gradually develop cholinergic deficits many years before symptom onset and may begin to smoke cigarettes during midlife as a form of self-medication. The aim of this study was to compare self-reported past smoking rates between those with and without cholinergic dementias, to determine if those who developed cholinergic dementias were more likely to smoke during midlife than those who did not. Methods. Retrospective cross-sectional study of past smoking status among patients treated at an outpatient clinic during a three-year period. Results. A total of 440 patients were evaluated during the study period, including 224 with cholinergic dementias and 216 with noncholinergic dementias and controls. Past smoking rates were greater among those with cholinergic dementias compared to those without cholinergic dementias (43.92% versus 26.96%, P=0.012). Additionally, smokers with cholinergic dementias reported significantly greater mean pack-years of smoking (P=0.038). Conclusions. Greater midlife smoking rates and greater pack-years of smoking were associated with cholinergic dementias. These results suggest midlife smoking may be an early indicator for those developing brain cholinergic deficits related to progressive dementing disorders and support initiating treatment prior to symptom onset in cholinergic dementias.http://dx.doi.org/10.1155/2014/423602 |
| spellingShingle | Kyle Dalrymple Erin K. Saito Natalie Diaz Julia Morrow Beau Nakamoto Aaron M. McMurtray Past Cigarette Smoking Is More Common among Those with Cholinergic Than Noncholinergic Dementias Neurology Research International |
| title | Past Cigarette Smoking Is More Common among Those with Cholinergic Than Noncholinergic Dementias |
| title_full | Past Cigarette Smoking Is More Common among Those with Cholinergic Than Noncholinergic Dementias |
| title_fullStr | Past Cigarette Smoking Is More Common among Those with Cholinergic Than Noncholinergic Dementias |
| title_full_unstemmed | Past Cigarette Smoking Is More Common among Those with Cholinergic Than Noncholinergic Dementias |
| title_short | Past Cigarette Smoking Is More Common among Those with Cholinergic Than Noncholinergic Dementias |
| title_sort | past cigarette smoking is more common among those with cholinergic than noncholinergic dementias |
| url | http://dx.doi.org/10.1155/2014/423602 |
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