Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease
Objectives The clinical course of thyroid eye disease (TED) is heterogeneous and predicting patients who may develop the severe sequelae of the disease is difficult. In this study, we evaluated the longitudinal association between changes in serum thyroid-stimulating hormone (TSH) receptor antibody...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-06-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e050337.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832584148174241792 |
|---|---|
| author | Kyung In Woo Suk-Woo Yang Jeong Kyu Lee Sang In Khwarg Jin Sook Yoon Sehyun Baek Jae Wook Yang JaeSang Ko Koung Hoon Kook Sang Duck Kim Jun Hyuk Son Helen Lew Sung Bok Lee Jae Woo Jang Hee Young Choi Mi Jung Chi |
| author_facet | Kyung In Woo Suk-Woo Yang Jeong Kyu Lee Sang In Khwarg Jin Sook Yoon Sehyun Baek Jae Wook Yang JaeSang Ko Koung Hoon Kook Sang Duck Kim Jun Hyuk Son Helen Lew Sung Bok Lee Jae Woo Jang Hee Young Choi Mi Jung Chi |
| collection | DOAJ |
| description | Objectives The clinical course of thyroid eye disease (TED) is heterogeneous and predicting patients who may develop the severe sequelae of the disease is difficult. In this study, we evaluated the longitudinal association between changes in serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb) levels and course of disease activity and severity over time.Design This was a multicentre, prospective, observational study.Setting Fifteen tertiary care oculoplastic service centres in Korea.Participants Seventy-six patients with newly diagnosed TED were included and followed up for 12 months.Methods We evaluated clinical characteristics and serum TRAb levels at baseline, 6 and 12 months of TED diagnosis. Additionally, we analysed longitudinal associations between the serum TRAb levels and clinical activity score (CAS), no signs or symptoms, only signs, soft tissue involvement, proptosis, extraocular muscle involvement, corneal involvement, sight loss (NOSPECS) score and proptosis.Results Thyroid-stimulating immunoglobulin (TSI) and TSH-binding inhibitory immunoglobulin (TBII) levels decreased during the 1-year follow-up, whereas disease activity measured using CAS decreased mainly in the first 6 months. Disease severity measured using NOSPECS score and proptosis remained unchanged. Moreover, inter-person differences in TBII levels were associated with CAS, NOSPECS score and proptosis over time, whereas inter-person differences in TSI levels were associated with NOSPECS score. Subgroup analysis of patients with a baseline CAS≥4 demonstrated that within-person changes in TSI levels affected the CAS and NOSPECS score.Conclusions Follow-up measurement of serum TSI and TBII levels may help evaluate TED prognosis and enable accurate clinical decision-making. |
| format | Article |
| id | doaj-art-e4dff9b9924f4a7ba79fc5ead6427283 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e4dff9b9924f4a7ba79fc5ead64272832025-01-27T15:25:12ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-050337Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease 0Kyung In Woo1Suk-Woo YangJeong Kyu Lee2Sang In KhwargJin Sook Yoon3Sehyun BaekJae Wook Yang4JaeSang Ko5Koung Hoon Kook6Sang Duck KimJun Hyuk SonHelen LewSung Bok LeeJae Woo JangHee Young ChoiMi Jung ChiNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USADepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)National University Singapore Saw Swee Hock School of Public Health, SingaporeDepartment of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)Department of Ophthalmology, Inje University College of Medicine, Inje University Busan Paik Hospital, Busan, Korea (the Republic of)Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea (the Republic of)Objectives The clinical course of thyroid eye disease (TED) is heterogeneous and predicting patients who may develop the severe sequelae of the disease is difficult. In this study, we evaluated the longitudinal association between changes in serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb) levels and course of disease activity and severity over time.Design This was a multicentre, prospective, observational study.Setting Fifteen tertiary care oculoplastic service centres in Korea.Participants Seventy-six patients with newly diagnosed TED were included and followed up for 12 months.Methods We evaluated clinical characteristics and serum TRAb levels at baseline, 6 and 12 months of TED diagnosis. Additionally, we analysed longitudinal associations between the serum TRAb levels and clinical activity score (CAS), no signs or symptoms, only signs, soft tissue involvement, proptosis, extraocular muscle involvement, corneal involvement, sight loss (NOSPECS) score and proptosis.Results Thyroid-stimulating immunoglobulin (TSI) and TSH-binding inhibitory immunoglobulin (TBII) levels decreased during the 1-year follow-up, whereas disease activity measured using CAS decreased mainly in the first 6 months. Disease severity measured using NOSPECS score and proptosis remained unchanged. Moreover, inter-person differences in TBII levels were associated with CAS, NOSPECS score and proptosis over time, whereas inter-person differences in TSI levels were associated with NOSPECS score. Subgroup analysis of patients with a baseline CAS≥4 demonstrated that within-person changes in TSI levels affected the CAS and NOSPECS score.Conclusions Follow-up measurement of serum TSI and TBII levels may help evaluate TED prognosis and enable accurate clinical decision-making.https://bmjopen.bmj.com/content/12/6/e050337.full |
| spellingShingle | Kyung In Woo Suk-Woo Yang Jeong Kyu Lee Sang In Khwarg Jin Sook Yoon Sehyun Baek Jae Wook Yang JaeSang Ko Koung Hoon Kook Sang Duck Kim Jun Hyuk Son Helen Lew Sung Bok Lee Jae Woo Jang Hee Young Choi Mi Jung Chi Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease BMJ Open |
| title | Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease |
| title_full | Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease |
| title_fullStr | Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease |
| title_full_unstemmed | Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease |
| title_short | Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease |
| title_sort | longitudinal association of thyroid stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease |
| url | https://bmjopen.bmj.com/content/12/6/e050337.full |
| work_keys_str_mv | AT longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT kyunginwoo longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT sukwooyang longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT jeongkyulee longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT sanginkhwarg longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT jinsookyoon longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT sehyunbaek longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT jaewookyang longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT jaesangko longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT kounghoonkook longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT sangduckkim longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT junhyukson longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT helenlew longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT sungboklee longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT jaewoojang longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT heeyoungchoi longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease AT mijungchi longitudinalassociationofthyroidstimulatingimmunoglobulinlevelswithclinicalcharacteristicsinthyroideyedisease |