Dynamic changes in blood concentrations of nitrite/nitrate and methemoglobin in patients after lung transplantation during treatment with inhaled nitric oxide
Understanding of the nitric oxide (NO) role in the pathogenesis of acute and chronic disorders of the pulmonary circulation contributed to the introduction of inhaled NO (iNO) in the complex therapy of patients after lung transplantation. Inhaled NO can form methemoglobin (MetHb) and nitrate. The ai...
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2016-02-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/96 |
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| author | M. Sh. Khubutiya E. V. Klychnikova E. V. Tazina T. A. Tarabrin E. I. Pervakova A. A. Romanov O. A. Kurilova M. A. Godkov |
| author_facet | M. Sh. Khubutiya E. V. Klychnikova E. V. Tazina T. A. Tarabrin E. I. Pervakova A. A. Romanov O. A. Kurilova M. A. Godkov |
| author_sort | M. Sh. Khubutiya |
| collection | DOAJ |
| description | Understanding of the nitric oxide (NO) role in the pathogenesis of acute and chronic disorders of the pulmonary circulation contributed to the introduction of inhaled NO (iNO) in the complex therapy of patients after lung transplantation. Inhaled NO can form methemoglobin (MetHb) and nitrate. The aim of the study was to investigate the relationship between iNO and nitrite/nitrate (NOx) and MetHb levels in the blood serum of 7 patients after lung transplantation. Duration of iNO therapy was 3±1 days, the data were reviewed at 1 to 10 days after transplantation. Patients showed significant improvement of the NOx level from day 1 to 5 after surgery, meanwhile the MetHb concentration remained within the normal range. The significant positive correlations were found between iNO and NOx concentrations, between iNO and MetHb concentrations, and between NOx and MetHb concentrations. The obtained results suggest that when using iNO in patients in lung transplantation, the concentration of the administered iNO, as well as blood levels of MetHb and NOx must be closely monitored. |
| format | Article |
| id | doaj-art-e4dfa67b6d824e9280098b100d2282bf |
| institution | Kabale University |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2016-02-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-e4dfa67b6d824e9280098b100d2282bf2025-08-20T03:35:07ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092016-02-010461196Dynamic changes in blood concentrations of nitrite/nitrate and methemoglobin in patients after lung transplantation during treatment with inhaled nitric oxideM. Sh. Khubutiya0E. V. Klychnikova1E. V. Tazina2T. A. Tarabrin3E. I. Pervakova4A. A. Romanov5O. A. Kurilova6M. A. Godkov7N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, MoscowN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, MoscowUnderstanding of the nitric oxide (NO) role in the pathogenesis of acute and chronic disorders of the pulmonary circulation contributed to the introduction of inhaled NO (iNO) in the complex therapy of patients after lung transplantation. Inhaled NO can form methemoglobin (MetHb) and nitrate. The aim of the study was to investigate the relationship between iNO and nitrite/nitrate (NOx) and MetHb levels in the blood serum of 7 patients after lung transplantation. Duration of iNO therapy was 3±1 days, the data were reviewed at 1 to 10 days after transplantation. Patients showed significant improvement of the NOx level from day 1 to 5 after surgery, meanwhile the MetHb concentration remained within the normal range. The significant positive correlations were found between iNO and NOx concentrations, between iNO and MetHb concentrations, and between NOx and MetHb concentrations. The obtained results suggest that when using iNO in patients in lung transplantation, the concentration of the administered iNO, as well as blood levels of MetHb and NOx must be closely monitored.https://www.jtransplantologiya.ru/jour/article/view/96lung transplantationinhaled nitric oxidenitrite/nitratemethemoglobin |
| spellingShingle | M. Sh. Khubutiya E. V. Klychnikova E. V. Tazina T. A. Tarabrin E. I. Pervakova A. A. Romanov O. A. Kurilova M. A. Godkov Dynamic changes in blood concentrations of nitrite/nitrate and methemoglobin in patients after lung transplantation during treatment with inhaled nitric oxide Трансплантология (Москва) lung transplantation inhaled nitric oxide nitrite/nitrate methemoglobin |
| title | Dynamic changes in blood concentrations of nitrite/nitrate and methemoglobin in patients after lung transplantation during treatment with inhaled nitric oxide |
| title_full | Dynamic changes in blood concentrations of nitrite/nitrate and methemoglobin in patients after lung transplantation during treatment with inhaled nitric oxide |
| title_fullStr | Dynamic changes in blood concentrations of nitrite/nitrate and methemoglobin in patients after lung transplantation during treatment with inhaled nitric oxide |
| title_full_unstemmed | Dynamic changes in blood concentrations of nitrite/nitrate and methemoglobin in patients after lung transplantation during treatment with inhaled nitric oxide |
| title_short | Dynamic changes in blood concentrations of nitrite/nitrate and methemoglobin in patients after lung transplantation during treatment with inhaled nitric oxide |
| title_sort | dynamic changes in blood concentrations of nitrite nitrate and methemoglobin in patients after lung transplantation during treatment with inhaled nitric oxide |
| topic | lung transplantation inhaled nitric oxide nitrite/nitrate methemoglobin |
| url | https://www.jtransplantologiya.ru/jour/article/view/96 |
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