Activation of the Rat P2X7 Receptor by Functionally Different ATP Activation Sites

Activation of the Rat P2X7 Receptor by Functionally Different ATP Activation Sites

The homotrimeric P2X7 receptor (P2X7R) contains three ATP<sup>4−</sup> binding sites in its ectodomain. Here, we investigated the role of individual ATP<sup>4−</sup> activation sites in rat P2X7R (rP2X7R) using trimeric concatemers consisting of either three wild-type subunit...

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Bibliographic Details
Main Authors: Fritz Markwardt, Malte Berthold, Sanaria Hawro Yakoob, Günther Schmalzing
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
purinoceptor
P2X7
activation
structure
kinetics
voltage clamp
Online Access:https://www.mdpi.com/2073-4409/14/12/855
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