Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database
Abstract Background Pressure ulcer is a significant issue that cannot be overlooked in septic patients. This study aims to explore the impact of pressure ulcers on the 28 day mortality rate of septic patients. Methods The data for this study were obtained from the MIMIC-IV v3.0 database. Univariate...
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BMC
2025-07-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02909-5 |
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| author | Yan Zhu Jin-yu Lei Jie Zou Xue-feng Liu Wen-Fang Li Feng Cao |
| author_facet | Yan Zhu Jin-yu Lei Jie Zou Xue-feng Liu Wen-Fang Li Feng Cao |
| author_sort | Yan Zhu |
| collection | DOAJ |
| description | Abstract Background Pressure ulcer is a significant issue that cannot be overlooked in septic patients. This study aims to explore the impact of pressure ulcers on the 28 day mortality rate of septic patients. Methods The data for this study were obtained from the MIMIC-IV v3.0 database. Univariate and multivariate analysis methods were employed to conduct an in-depth exploration of the 28 day mortality rate of septic patients. Kaplan–Meier survival curves were plotted to verify the influence of pressure ulcer on the 28 day mortality rate of septic patients. In addition, subgroup analysis was carried out to reveal the relationship between pressure ulcer and other confounding factors. Results Among the 20,280 patients included in the MIMIC-IV cohort, 880 had pressure ulcers. Both the results of univariate and multivariate analyses showed that pressure ulcers were a significant influencing factor for the 28 day mortality rate of septic patients (p = 0.002). The survival curves indicated that the 28 day mortality rate of septic patients with pressure ulcers was significantly higher than that of septic patients without pressure ulcers. The Cox proportional hazards model analysis demonstrated that septic patients with pressure ulcers had a 28 day mortality hazard ratio of 1.30 compared with septic patients without pressure ulcers. The results of subgroup analysis suggested that more attention should be paid to the prevention of pressure ulcers in patients younger than 65 years old, male patients, patients with a SOFA score greater than 3, and patients with comorbid diabetes or renal diseases . Conclusion Pressure ulcers may independently associate with increased mortality in septic patients. |
| format | Article |
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| institution | DOAJ |
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| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | European Journal of Medical Research |
| spelling | doaj-art-e4da6b4c67dd4bcb91f5df09fe7f0a292025-08-20T03:04:23ZengBMCEuropean Journal of Medical Research2047-783X2025-07-0130111010.1186/s40001-025-02909-5Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV databaseYan Zhu0Jin-yu Lei1Jie Zou2Xue-feng Liu3Wen-Fang Li4Feng Cao5Department of Emergency and Critical Care, Shanghai Changzheng Hospital of Naval Medical UniversityDepartment of Emergency and Critical Care, Shanghai Changzheng Hospital of Naval Medical UniversityDepartment of Information Science and Engineering, Xinjiang College of Science & TechnologyDepartment of Emergency and Critical Care, Shanghai Changzheng Hospital of Naval Medical UniversityDepartment of Emergency and Critical Care, Shanghai Changzheng Hospital of Naval Medical UniversityDepartment of Emergency and Critical Care, Shanghai Changzheng Hospital of Naval Medical UniversityAbstract Background Pressure ulcer is a significant issue that cannot be overlooked in septic patients. This study aims to explore the impact of pressure ulcers on the 28 day mortality rate of septic patients. Methods The data for this study were obtained from the MIMIC-IV v3.0 database. Univariate and multivariate analysis methods were employed to conduct an in-depth exploration of the 28 day mortality rate of septic patients. Kaplan–Meier survival curves were plotted to verify the influence of pressure ulcer on the 28 day mortality rate of septic patients. In addition, subgroup analysis was carried out to reveal the relationship between pressure ulcer and other confounding factors. Results Among the 20,280 patients included in the MIMIC-IV cohort, 880 had pressure ulcers. Both the results of univariate and multivariate analyses showed that pressure ulcers were a significant influencing factor for the 28 day mortality rate of septic patients (p = 0.002). The survival curves indicated that the 28 day mortality rate of septic patients with pressure ulcers was significantly higher than that of septic patients without pressure ulcers. The Cox proportional hazards model analysis demonstrated that septic patients with pressure ulcers had a 28 day mortality hazard ratio of 1.30 compared with septic patients without pressure ulcers. The results of subgroup analysis suggested that more attention should be paid to the prevention of pressure ulcers in patients younger than 65 years old, male patients, patients with a SOFA score greater than 3, and patients with comorbid diabetes or renal diseases . Conclusion Pressure ulcers may independently associate with increased mortality in septic patients.https://doi.org/10.1186/s40001-025-02909-5Pressure ulcerSepsisKaplan–Meier curvesSensitivity analysis |
| spellingShingle | Yan Zhu Jin-yu Lei Jie Zou Xue-feng Liu Wen-Fang Li Feng Cao Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database European Journal of Medical Research Pressure ulcer Sepsis Kaplan–Meier curves Sensitivity analysis |
| title | Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database |
| title_full | Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database |
| title_fullStr | Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database |
| title_full_unstemmed | Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database |
| title_short | Association between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database |
| title_sort | association between pressure ulcer and 28 day mortality in septic patients a retrospective study based on the mimic iv database |
| topic | Pressure ulcer Sepsis Kaplan–Meier curves Sensitivity analysis |
| url | https://doi.org/10.1186/s40001-025-02909-5 |
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