Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature
A 38-year-old man with near fatal asthma requiring intubation and invasive mechanical ventilation (IMV) was transferred to our hospital. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) was initiated due to hypotension and mediastinal emphysema secondary to barotrauma. Since high-dose syste...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Respiratory Medicine Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007125000590 |
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| _version_ | 1850144550831521792 |
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| author | Mako Nakajima Masashi Matsuyama Yuki Yamazaki Hiroya Sunabe Yuta Takahashi Keishun Boku Takeshi Miura Tomohiro Tamura Yoshiaki Inoue Nobuyuki Hizawa |
| author_facet | Mako Nakajima Masashi Matsuyama Yuki Yamazaki Hiroya Sunabe Yuta Takahashi Keishun Boku Takeshi Miura Tomohiro Tamura Yoshiaki Inoue Nobuyuki Hizawa |
| author_sort | Mako Nakajima |
| collection | DOAJ |
| description | A 38-year-old man with near fatal asthma requiring intubation and invasive mechanical ventilation (IMV) was transferred to our hospital. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) was initiated due to hypotension and mediastinal emphysema secondary to barotrauma. Since high-dose systemic corticosteroid therapy failed to relieve the severe bronchospasm, a single dose of tezepelumab was administered on a compassionate basis. This intervention resulted in successful extubation 7 days later. This is a rare case in which a biologic agent was used as a rescue therapy for near fatal asthma. This case is presented along with a review of the relevant literature. |
| format | Article |
| id | doaj-art-e4d543daf9d546c88d3986f00024af7f |
| institution | OA Journals |
| issn | 2213-0071 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj-art-e4d543daf9d546c88d3986f00024af7f2025-08-20T02:28:19ZengElsevierRespiratory Medicine Case Reports2213-00712025-01-015510222310.1016/j.rmcr.2025.102223Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literatureMako Nakajima0Masashi Matsuyama1Yuki Yamazaki2Hiroya Sunabe3Yuta Takahashi4Keishun Boku5Takeshi Miura6Tomohiro Tamura7Yoshiaki Inoue8Nobuyuki Hizawa9Department of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; Corresponding author. 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.Department of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Emergency and Critical Care Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Emergency and Critical Care Medicine, University of Tsukuba, Ibaraki, JapanRespiratory Center, Ibaraki Prefectural Central Hospital, Kasama, JapanDepartment of Emergency and Critical Care Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanA 38-year-old man with near fatal asthma requiring intubation and invasive mechanical ventilation (IMV) was transferred to our hospital. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) was initiated due to hypotension and mediastinal emphysema secondary to barotrauma. Since high-dose systemic corticosteroid therapy failed to relieve the severe bronchospasm, a single dose of tezepelumab was administered on a compassionate basis. This intervention resulted in successful extubation 7 days later. This is a rare case in which a biologic agent was used as a rescue therapy for near fatal asthma. This case is presented along with a review of the relevant literature.http://www.sciencedirect.com/science/article/pii/S2213007125000590Near fatal asthmaVeno-venous extracorporeal membrane oxygenation (VV-ECMO)BiologicsTezepelumab |
| spellingShingle | Mako Nakajima Masashi Matsuyama Yuki Yamazaki Hiroya Sunabe Yuta Takahashi Keishun Boku Takeshi Miura Tomohiro Tamura Yoshiaki Inoue Nobuyuki Hizawa Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature Respiratory Medicine Case Reports Near fatal asthma Veno-venous extracorporeal membrane oxygenation (VV-ECMO) Biologics Tezepelumab |
| title | Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature |
| title_full | Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature |
| title_fullStr | Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature |
| title_full_unstemmed | Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature |
| title_short | Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature |
| title_sort | compassionate use of tezepelumab in near fatal asthma a case report and review of the literature |
| topic | Near fatal asthma Veno-venous extracorporeal membrane oxygenation (VV-ECMO) Biologics Tezepelumab |
| url | http://www.sciencedirect.com/science/article/pii/S2213007125000590 |
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