Diagnosis of precancerous lesions of the breast
The purpose of this work is to determine the optimal markers for clarifying the degree of proliferative activity in benign breast lesions, which can be used in surgical treatment planning. Materials and methods. The immunocytochemical results of tumor proliferation marker (Ki-67), cancer-embryoni...
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Zaporizhzhia State Medical and Pharmaceutical University
2020-06-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/204917/205982 |
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| author | D. I. Kebalo N. P. Miroshnykova O. P. Shershniova S. M. Pashchenko E. D. Zvantseva |
| author_facet | D. I. Kebalo N. P. Miroshnykova O. P. Shershniova S. M. Pashchenko E. D. Zvantseva |
| author_sort | D. I. Kebalo |
| collection | DOAJ |
| description | The purpose of this work is to determine the optimal markers for clarifying the degree of proliferative activity in benign breast lesions, which can be used in surgical treatment planning.
Materials and methods. The immunocytochemical results of tumor proliferation marker (Ki-67), cancer-embryonic antigen (CEA), matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) expression were studied in biopsy samples collected from 108 patients with benign breast lesions and 49 patients with breast cancer.
Results. It was found that the proliferative processes rising was accompanied by an increase in the number of patients with expression of Ki-67 to 28.0 %, CEA to 44.0 %, VEGF to 80.0 %, and a decrease in the number of patients with MMP-9 expression from 75.0 % to 36.4 %. Among patients with breast cancer, cells expressing Ki-67 were observed in 36.8 %, MMP-9 in 20.7 %, CEA in 36.4 %, VEGF in 48.3 %. The results indicate the presence of a neoplastic potential in benign lesions and its enhancement with an increase in proliferative properties.
Conclusions. This diagnostic method can be used to determine the malignant potential in benign breast lesions and for therapeutic decision making. |
| format | Article |
| id | doaj-art-e4d33fdeee1f4c17872265e2f196ae53 |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-e4d33fdeee1f4c17872265e2f196ae532025-08-20T02:21:18ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102020-06-0122334434910.14739/2310-1210.2020.3.204917Diagnosis of precancerous lesions of the breastD. I. Kebalo0N. P. Miroshnykova1O. P. Shershniova2S. M. Pashchenko3E. D. Zvantseva4CRDC COMREC, Zaporizhzhia, Ukraine CRDC COMREC, Zaporizhzhia, UkraineSI “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine” Zaporizhzhia Regional Clinical Oncology Hospital, UkraineCRDC COMREC, Zaporizhzhia, UkraineThe purpose of this work is to determine the optimal markers for clarifying the degree of proliferative activity in benign breast lesions, which can be used in surgical treatment planning. Materials and methods. The immunocytochemical results of tumor proliferation marker (Ki-67), cancer-embryonic antigen (CEA), matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) expression were studied in biopsy samples collected from 108 patients with benign breast lesions and 49 patients with breast cancer. Results. It was found that the proliferative processes rising was accompanied by an increase in the number of patients with expression of Ki-67 to 28.0 %, CEA to 44.0 %, VEGF to 80.0 %, and a decrease in the number of patients with MMP-9 expression from 75.0 % to 36.4 %. Among patients with breast cancer, cells expressing Ki-67 were observed in 36.8 %, MMP-9 in 20.7 %, CEA in 36.4 %, VEGF in 48.3 %. The results indicate the presence of a neoplastic potential in benign lesions and its enhancement with an increase in proliferative properties. Conclusions. This diagnostic method can be used to determine the malignant potential in benign breast lesions and for therapeutic decision making.http://zmj.zsmu.edu.ua/article/view/204917/205982mammary glandbiochemical tumor markersimmunocytochemistry |
| spellingShingle | D. I. Kebalo N. P. Miroshnykova O. P. Shershniova S. M. Pashchenko E. D. Zvantseva Diagnosis of precancerous lesions of the breast Zaporožskij Medicinskij Žurnal mammary gland biochemical tumor markers immunocytochemistry |
| title | Diagnosis of precancerous lesions of the breast |
| title_full | Diagnosis of precancerous lesions of the breast |
| title_fullStr | Diagnosis of precancerous lesions of the breast |
| title_full_unstemmed | Diagnosis of precancerous lesions of the breast |
| title_short | Diagnosis of precancerous lesions of the breast |
| title_sort | diagnosis of precancerous lesions of the breast |
| topic | mammary gland biochemical tumor markers immunocytochemistry |
| url | http://zmj.zsmu.edu.ua/article/view/204917/205982 |
| work_keys_str_mv | AT dikebalo diagnosisofprecancerouslesionsofthebreast AT npmiroshnykova diagnosisofprecancerouslesionsofthebreast AT opshershniova diagnosisofprecancerouslesionsofthebreast AT smpashchenko diagnosisofprecancerouslesionsofthebreast AT edzvantseva diagnosisofprecancerouslesionsofthebreast |