Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy
Objective. To elucidate the time course of tumor metabolism during the first 3 months after 90Y-ibritumomab tiuxetan radioimmunotherapy (RIT) in patients with refractory malignant lymphoma. Materials and Methods. Seven patients with recurrent follicular lymphoma underwent FDG-PET imaging before and...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/368947 |
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| author | Miwako Takahashi Toshimitsu Momose Keitaro Koyama Motoshi Ichikawa Mineo Kurokawa Kuni Ohtomo |
| author_facet | Miwako Takahashi Toshimitsu Momose Keitaro Koyama Motoshi Ichikawa Mineo Kurokawa Kuni Ohtomo |
| author_sort | Miwako Takahashi |
| collection | DOAJ |
| description | Objective. To elucidate the time course of tumor metabolism during the first 3 months after 90Y-ibritumomab tiuxetan radioimmunotherapy (RIT) in patients with refractory malignant lymphoma. Materials and Methods. Seven patients with recurrent follicular lymphoma underwent FDG-PET imaging before and after 1-, 4-, and 12-week RIT with 90Y-ibritumomab tiuxetan. Tumor metabolic activity on FDG-PET scans was assessed as the maximum standard uptake value (SUVmax). Results. Decrease in metabolism was detected 1 week after RIT. In the most decreased lesion, SUVmax decreased to 20% of the baseline value during the first week. Most lesions continued to decrease for up to 4 weeks. Some lesions showed increased metabolism from 4 to 12 weeks, while the level of FDG accumulations at 12 weeks was still lower than the baseline. Conclusions. Tumor response to RIT could be observed as early as 1 week after the administration of RIT. After tumor activity decreases, the metabolism may increase at least between 4 and 12 weeks. It suggests that the metabolic changes should be carefully evaluated during this period. |
| format | Article |
| id | doaj-art-e4d1d6b5d8144424bc74527fa28c593b |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e4d1d6b5d8144424bc74527fa28c593b2025-02-03T06:44:18ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/368947368947Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan RadioimmunotherapyMiwako Takahashi0Toshimitsu Momose1Keitaro Koyama2Motoshi Ichikawa3Mineo Kurokawa4Kuni Ohtomo5Department of Radiology, Graduate School of Medicine, The University of Tokyo, 3-1 Hongo 7-Chome, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 3-1 Hongo 7-Chome, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 3-1 Hongo 7-Chome, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 3-1 Hongo 7-Chome, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 3-1 Hongo 7-Chome, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 3-1 Hongo 7-Chome, Bunkyo-ku, Tokyo 113-8655, JapanObjective. To elucidate the time course of tumor metabolism during the first 3 months after 90Y-ibritumomab tiuxetan radioimmunotherapy (RIT) in patients with refractory malignant lymphoma. Materials and Methods. Seven patients with recurrent follicular lymphoma underwent FDG-PET imaging before and after 1-, 4-, and 12-week RIT with 90Y-ibritumomab tiuxetan. Tumor metabolic activity on FDG-PET scans was assessed as the maximum standard uptake value (SUVmax). Results. Decrease in metabolism was detected 1 week after RIT. In the most decreased lesion, SUVmax decreased to 20% of the baseline value during the first week. Most lesions continued to decrease for up to 4 weeks. Some lesions showed increased metabolism from 4 to 12 weeks, while the level of FDG accumulations at 12 weeks was still lower than the baseline. Conclusions. Tumor response to RIT could be observed as early as 1 week after the administration of RIT. After tumor activity decreases, the metabolism may increase at least between 4 and 12 weeks. It suggests that the metabolic changes should be carefully evaluated during this period.http://dx.doi.org/10.1155/2014/368947 |
| spellingShingle | Miwako Takahashi Toshimitsu Momose Keitaro Koyama Motoshi Ichikawa Mineo Kurokawa Kuni Ohtomo Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy The Scientific World Journal |
| title | Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy |
| title_full | Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy |
| title_fullStr | Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy |
| title_full_unstemmed | Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy |
| title_short | Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy |
| title_sort | dynamic metabolic changes during the first 3 months after 90y ibritumomab tiuxetan radioimmunotherapy |
| url | http://dx.doi.org/10.1155/2014/368947 |
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