Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach
The scientific community has united to raise awareness of Alzheimer's disease (AD) as a critical condition for future generations because recent predictions indicate that it will become common among the elderly within a few years. Nevertheless, the intricacies of the disease's progression...
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Elsevier
2025-06-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750025000241 |
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| author | Ahmed M. Almehdi Doha H. Aboubaker Rania Hamdy Ali El-Keblawy |
| author_facet | Ahmed M. Almehdi Doha H. Aboubaker Rania Hamdy Ali El-Keblawy |
| author_sort | Ahmed M. Almehdi |
| collection | DOAJ |
| description | The scientific community has united to raise awareness of Alzheimer's disease (AD) as a critical condition for future generations because recent predictions indicate that it will become common among the elderly within a few years. Nevertheless, the intricacies of the disease's progression demand exhaustive investigations to unravel its potential mechanisms. Only then can clinicians develop more efficacious therapeutic strategies. Cognitive impairment caused by amyloid aggregation, the development of hyperphosphorylated neurofibrillary tangles, and a malfunctioning cholinergic system are the hallmarks of AD. Even after the disease has started, brain tissue integrity may degenerate. The physiological characteristics of the highly selective blood-brain barrier and the electrostatic charge of the nanoporous extracellular matrix have long placed restrictions on the treatment of brain disorders. A prospective revolution in drug delivery for the treatment of AD is the use of nanomedicine. It depends on enhancing the way that medications are distributed pharmacokinetically throughout the central nervous system. Several types of nanoparticles (Nps) are available thanks to nanotechnology, and these Nps could target the brain and have a long half-life with few systemic side effects and motor problems. With the latest technological developments, scientists are working to develop unique approaches for the treatment of AD. To evaluate the prospective uses of medicinal plants, their components, and different nanomedicine techniques, it was determined that this literature study was necessary. To provide an overview of the various challenges and approaches related to using nanoparticles (NPs) to combat Alzheimer's disease (AD), this introductory review article was developed. |
| format | Article |
| id | doaj-art-e4cc2d3e1b84427999b08a8057a8efc4 |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-e4cc2d3e1b84427999b08a8057a8efc42025-01-29T05:01:18ZengElsevierToxicology Reports2214-75002025-06-0114101906Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approachAhmed M. Almehdi0Doha H. Aboubaker1Rania Hamdy2Ali El-Keblawy3Department of Applied Biology, College of Sciences, University of Sharjah, P.O.Box 27272, Sharjah, UAEResearch Institute for Sciences and Engineering (RISE), University of Sharjah, P.O. Box 27272, Sharjah, UAE; Medicinal and Aromatic Plants Dept., Pharmaceutical and Drug Industries institute, National Research Centre, Cairo, Egypt; Corresponding author at: Research Institute for Sciences and Engineering (RISE), University of Sharjah, P.O. Box 27272, Sharjah, UAE.Research Institute for Sciences and Engineering (RISE), University of Sharjah, P.O. Box 27272, Sharjah, UAEDepartment of Applied Biology, College of Sciences, University of Sharjah, P.O.Box 27272, Sharjah, UAE; Department of Biology, Faculty of Science, Al-Arish University, EgyptThe scientific community has united to raise awareness of Alzheimer's disease (AD) as a critical condition for future generations because recent predictions indicate that it will become common among the elderly within a few years. Nevertheless, the intricacies of the disease's progression demand exhaustive investigations to unravel its potential mechanisms. Only then can clinicians develop more efficacious therapeutic strategies. Cognitive impairment caused by amyloid aggregation, the development of hyperphosphorylated neurofibrillary tangles, and a malfunctioning cholinergic system are the hallmarks of AD. Even after the disease has started, brain tissue integrity may degenerate. The physiological characteristics of the highly selective blood-brain barrier and the electrostatic charge of the nanoporous extracellular matrix have long placed restrictions on the treatment of brain disorders. A prospective revolution in drug delivery for the treatment of AD is the use of nanomedicine. It depends on enhancing the way that medications are distributed pharmacokinetically throughout the central nervous system. Several types of nanoparticles (Nps) are available thanks to nanotechnology, and these Nps could target the brain and have a long half-life with few systemic side effects and motor problems. With the latest technological developments, scientists are working to develop unique approaches for the treatment of AD. To evaluate the prospective uses of medicinal plants, their components, and different nanomedicine techniques, it was determined that this literature study was necessary. To provide an overview of the various challenges and approaches related to using nanoparticles (NPs) to combat Alzheimer's disease (AD), this introductory review article was developed.http://www.sciencedirect.com/science/article/pii/S2214750025000241Biogenic approachGreen chemistryMetallic nanoparticlesAlzheimer's disease |
| spellingShingle | Ahmed M. Almehdi Doha H. Aboubaker Rania Hamdy Ali El-Keblawy Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach Toxicology Reports Biogenic approach Green chemistry Metallic nanoparticles Alzheimer's disease |
| title | Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach |
| title_full | Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach |
| title_fullStr | Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach |
| title_full_unstemmed | Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach |
| title_short | Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach |
| title_sort | nanotherapeutic smart approaches for combating alzheimer s disease and overcoming existing obstacles a novel eco friendly green approach |
| topic | Biogenic approach Green chemistry Metallic nanoparticles Alzheimer's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2214750025000241 |
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