Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters
<b>Background/Objectives:</b> Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall. Men with abnormal semen parameters have a significantly increased risk of aneuploidy, presenting...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/5/1191 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849711890846973952 |
|---|---|
| author | Mahira Ismayilova Aytakin Hasanova Andrei Semikhodskii |
| author_facet | Mahira Ismayilova Aytakin Hasanova Andrei Semikhodskii |
| author_sort | Mahira Ismayilova |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall. Men with abnormal semen parameters have a significantly increased risk of aneuploidy, presenting a serious concern in programmes of assisted reproductive technologies. Recently, the introduction of preimplantation genetic testing for aneuploidies (PGT-A) has increased the pregnancy rate and live births. We investigated the effect of PGT-A on the success of IVF treatment in couples with the male factor of infertility. <b>Methods:</b> Two experimental groups and one control group were studied: Group A (110 couples)—male partners with abnormal semen parameters, with PGT-A; Group B (110 couples)—male partners with abnormal semen parameters, without PGT-A; and Group C (105 couples)—control, male partners with normal spermograms, with PGT-A. A Day 3 blastomere biopsy was followed by FISH-based PGT-A. A total of 880 embryos from Group A and 890 embryos from Group C was analysed. <b>Results:</b> In patients with abnormal semen parameters, embryonic aneuploidy was twice as common compared to the control (13.6% vs. 5.8%, <i>p</i> < 0.001). Group B had the lowest clinical pregnancy rate (28.2%), with two out of three pregnancies ending in a miscarriage. Only 10% of IVF cycles in this group resulted in live birth compared with 35.5% for Group A and 49.5% for Group C. <b>Conclusions:</b> Our data demonstrate that PGT-A screening as part of IVF treatment drastically increases the clinical pregnancy rate and chances of live birth in couples where male partners have semen abnormality. |
| format | Article |
| id | doaj-art-e4cb856e6041416892f6d68eb8b69ed6 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-e4cb856e6041416892f6d68eb8b69ed62025-08-20T03:14:30ZengMDPI AGBiomedicines2227-90592025-05-01135119110.3390/biomedicines13051191Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen ParametersMahira Ismayilova0Aytakin Hasanova1Andrei Semikhodskii2Central Clinic Hospital, 76 Parliament Ave., Baku AZ1006, AzerbaijanDepartment of Medical Biology and Genetics, Azerbaijan Medical University, Baku AZ1001, AzerbaijanMedical Genomics Ltd., 134 Somerset Road, London SW19 5HP, UK<b>Background/Objectives:</b> Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall. Men with abnormal semen parameters have a significantly increased risk of aneuploidy, presenting a serious concern in programmes of assisted reproductive technologies. Recently, the introduction of preimplantation genetic testing for aneuploidies (PGT-A) has increased the pregnancy rate and live births. We investigated the effect of PGT-A on the success of IVF treatment in couples with the male factor of infertility. <b>Methods:</b> Two experimental groups and one control group were studied: Group A (110 couples)—male partners with abnormal semen parameters, with PGT-A; Group B (110 couples)—male partners with abnormal semen parameters, without PGT-A; and Group C (105 couples)—control, male partners with normal spermograms, with PGT-A. A Day 3 blastomere biopsy was followed by FISH-based PGT-A. A total of 880 embryos from Group A and 890 embryos from Group C was analysed. <b>Results:</b> In patients with abnormal semen parameters, embryonic aneuploidy was twice as common compared to the control (13.6% vs. 5.8%, <i>p</i> < 0.001). Group B had the lowest clinical pregnancy rate (28.2%), with two out of three pregnancies ending in a miscarriage. Only 10% of IVF cycles in this group resulted in live birth compared with 35.5% for Group A and 49.5% for Group C. <b>Conclusions:</b> Our data demonstrate that PGT-A screening as part of IVF treatment drastically increases the clinical pregnancy rate and chances of live birth in couples where male partners have semen abnormality.https://www.mdpi.com/2227-9059/13/5/1191asthenozoospermiamale infertilityPGT-Aoligospermiaoligozoospermiateratozoospermia |
| spellingShingle | Mahira Ismayilova Aytakin Hasanova Andrei Semikhodskii Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters Biomedicines asthenozoospermia male infertility PGT-A oligospermia oligozoospermia teratozoospermia |
| title | Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters |
| title_full | Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters |
| title_fullStr | Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters |
| title_full_unstemmed | Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters |
| title_short | Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters |
| title_sort | preimplantation testing of human blastomeres for aneuploidy increases ivf success in couples where male partners had abnormal semen parameters |
| topic | asthenozoospermia male infertility PGT-A oligospermia oligozoospermia teratozoospermia |
| url | https://www.mdpi.com/2227-9059/13/5/1191 |
| work_keys_str_mv | AT mahiraismayilova preimplantationtestingofhumanblastomeresforaneuploidyincreasesivfsuccessincoupleswheremalepartnershadabnormalsemenparameters AT aytakinhasanova preimplantationtestingofhumanblastomeresforaneuploidyincreasesivfsuccessincoupleswheremalepartnershadabnormalsemenparameters AT andreisemikhodskii preimplantationtestingofhumanblastomeresforaneuploidyincreasesivfsuccessincoupleswheremalepartnershadabnormalsemenparameters |