Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies
Convectional drugs have failed to tackle the increasing public health challenge of Cancer and diabetes. Phytochemical conjugated nanoparticles are providing safer therapeutic alternatives to address this global challenge. Nanoparticles of nickel, iron and zinc are especially useful because of their...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024167904 |
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| author | Oghenejoboh Ufuoma Modupe Sonibare Oluwadayo Olatunde Muhammad Waseem Ekundayo Olusegun Sirajul Haq Ahad Amer Alsaiari Jamoliddin Razzokov |
| author_facet | Oghenejoboh Ufuoma Modupe Sonibare Oluwadayo Olatunde Muhammad Waseem Ekundayo Olusegun Sirajul Haq Ahad Amer Alsaiari Jamoliddin Razzokov |
| author_sort | Oghenejoboh Ufuoma Modupe |
| collection | DOAJ |
| description | Convectional drugs have failed to tackle the increasing public health challenge of Cancer and diabetes. Phytochemical conjugated nanoparticles are providing safer therapeutic alternatives to address this global challenge. Nanoparticles of nickel, iron and zinc are especially useful because of their magnetic properties, abilities to prevent the onset or slow the progression of these diseases. Nanoparticles of Ni/Fe and Ni/Fe/Zn were synthesized by hydrothermal reaction of Dalbergiella welwitschii extract with the respective metal chlorides, and were characterized using XRD, SEM, DLS, IR and UV- spectroscopy. The drug encapsulation and release profile of the ferrites was studied using curcumin as a test drug. the Anticancer and antidiabetic activities of the nanoparticles were investigated against MCF-7 breast cancer cell lines using the MTT assay and α-glucosidase enzyme inhibitory assay, respectively. The nanoparticles had high drug loading capacity (<10 %), promising cytotoxic activity against MCF-7 breast cancer cell lines and α-glucosidase inhibitory activities ranging between 5.6 and 13.4 μM comparable to standard drug acarbose (9.8 μM), respectively. Dalbergiella welwitschii mediated nanoparticles of Ni/Fe and Ni/Fe/Zn could be further explored as alternative therapeutic agents for cancer and diabetes. |
| format | Article |
| id | doaj-art-e4c54cc46ee744e98174059b694e232e |
| institution | DOAJ |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-e4c54cc46ee744e98174059b694e232e2025-08-20T02:46:43ZengElsevierHeliyon2405-84402025-01-01111e4075910.1016/j.heliyon.2024.e40759Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studiesOghenejoboh Ufuoma Modupe0Sonibare Oluwadayo Olatunde1Muhammad Waseem2Ekundayo Olusegun3Sirajul Haq4Ahad Amer Alsaiari5Jamoliddin Razzokov6Department of Chemistry, University of Ibadan, Ibadan, NigeriaDepartment of Chemistry, University of Ibadan, Ibadan, NigeriaDepartment of Chemistry, COMSATS University Islamabad, Islamabad, Pakistan; Corresponding author.Department of Chemistry, University of Ibadan, Ibadan, NigeriaDepartment of Clinical Laboratory Science, College of Applied Medical Science, Taif University, Taif, Saudi Arabia; Corresponding author.Department of Clinical Laboratory Science, College of Applied Medical Science, Taif University, Taif, Saudi ArabiaInstitute of Fundamental and Applied Research, National Research University TIIAME, Kori Niyoziy 39, 100000 Tashkent, Uzbekistan; Department of Natural Sciences, Shakhrisabz State Pedagogical Institute, Shakhrisabz Street 10, Kashkadarya 181301, Uzbekistan; Department of Biotechnology, Tashkent State Technical University, Universitet 2, Tashkent, 100095, UzbekistanConvectional drugs have failed to tackle the increasing public health challenge of Cancer and diabetes. Phytochemical conjugated nanoparticles are providing safer therapeutic alternatives to address this global challenge. Nanoparticles of nickel, iron and zinc are especially useful because of their magnetic properties, abilities to prevent the onset or slow the progression of these diseases. Nanoparticles of Ni/Fe and Ni/Fe/Zn were synthesized by hydrothermal reaction of Dalbergiella welwitschii extract with the respective metal chlorides, and were characterized using XRD, SEM, DLS, IR and UV- spectroscopy. The drug encapsulation and release profile of the ferrites was studied using curcumin as a test drug. the Anticancer and antidiabetic activities of the nanoparticles were investigated against MCF-7 breast cancer cell lines using the MTT assay and α-glucosidase enzyme inhibitory assay, respectively. The nanoparticles had high drug loading capacity (<10 %), promising cytotoxic activity against MCF-7 breast cancer cell lines and α-glucosidase inhibitory activities ranging between 5.6 and 13.4 μM comparable to standard drug acarbose (9.8 μM), respectively. Dalbergiella welwitschii mediated nanoparticles of Ni/Fe and Ni/Fe/Zn could be further explored as alternative therapeutic agents for cancer and diabetes.http://www.sciencedirect.com/science/article/pii/S2405844024167904Green synthesisDalbergiella welwitschiiNickel ferriteZinc doped nickel ferriteAnticancerAntidiabetics |
| spellingShingle | Oghenejoboh Ufuoma Modupe Sonibare Oluwadayo Olatunde Muhammad Waseem Ekundayo Olusegun Sirajul Haq Ahad Amer Alsaiari Jamoliddin Razzokov Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies Heliyon Green synthesis Dalbergiella welwitschii Nickel ferrite Zinc doped nickel ferrite Anticancer Antidiabetics |
| title | Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies |
| title_full | Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies |
| title_fullStr | Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies |
| title_full_unstemmed | Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies |
| title_short | Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies |
| title_sort | green hydrothermal synthesis of nickel and zinc doped nickel ferrite nanoparticles using dalbergiella welwitschii extracts and their biological studies |
| topic | Green synthesis Dalbergiella welwitschii Nickel ferrite Zinc doped nickel ferrite Anticancer Antidiabetics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024167904 |
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