Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats
Abstract To extract sinapine from rapeseed meal and investigate its antihypertensive function and mechanism. Blood pressure was measured before and after sinapine administration to evaluate sinapine’s immediate antihypertensive function. Twokidney, oneclip (2K1C) hypertensive rats were given sinapin...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-88926-0 |
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| author | Gaoyuan Yang Lin Zhu Yu Wang Yang Yu Xiaoguang Liu Jingbo Xia Yunjie Yang Huiguo Wang Baomin Feng |
| author_facet | Gaoyuan Yang Lin Zhu Yu Wang Yang Yu Xiaoguang Liu Jingbo Xia Yunjie Yang Huiguo Wang Baomin Feng |
| author_sort | Gaoyuan Yang |
| collection | DOAJ |
| description | Abstract To extract sinapine from rapeseed meal and investigate its antihypertensive function and mechanism. Blood pressure was measured before and after sinapine administration to evaluate sinapine’s immediate antihypertensive function. Twokidney, oneclip (2K1C) hypertensive rats were given sinapine for four weeks, with weekly blood pressure monitoring. The renin angiotensin aldosterone system (RAAS), including the levels of renin, angiotensin I (Ang I), angiotensin II (Ang II), aldosterone (ALD), angiotensin-converting enzyme (ACE) and other molecules related to blood pressure, such as NO, prostacyclin (PGI2), endothelin-1 (ET1), and thromboxane A2 (TXA2), were measured in rat blood. The impact of sinapine on vascular endothelial cell (A10) calcium and potassium channels was assessed using the patch-clamp technique. One-time or long-term administration of sinapine significantly reduced the rats’ systolic blood pressure (SBP), diastolic pressure (DBP), and mean blood pressure (MBP). Sinapine also decreased the levels of Ang II and ALD. Furthermore, sinapine effectively inhibited ACE activation, increased NO levels, and blocked L-type calcium channels. Sinapine has an antihypertensive function and achieves this process through multiple targets. |
| format | Article |
| id | doaj-art-e4c5371139294f3996856d46db4deac1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e4c5371139294f3996856d46db4deac12025-02-09T12:36:43ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-88926-0Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive ratsGaoyuan Yang0Lin Zhu1Yu Wang2Yang Yu3Xiaoguang Liu4Jingbo Xia5Yunjie Yang6Huiguo Wang7Baomin Feng8Guangzhou Sport UniversityGuangzhou Sport UniversityGuangzhou Sport UniversityGuangzhou Sport UniversityGuangzhou Sport UniversityGuangzhou Sport UniversityGuangzhou Sport UniversityGuangzhou Sport UniversityCollege of Life and Health, Dalian UniversityAbstract To extract sinapine from rapeseed meal and investigate its antihypertensive function and mechanism. Blood pressure was measured before and after sinapine administration to evaluate sinapine’s immediate antihypertensive function. Twokidney, oneclip (2K1C) hypertensive rats were given sinapine for four weeks, with weekly blood pressure monitoring. The renin angiotensin aldosterone system (RAAS), including the levels of renin, angiotensin I (Ang I), angiotensin II (Ang II), aldosterone (ALD), angiotensin-converting enzyme (ACE) and other molecules related to blood pressure, such as NO, prostacyclin (PGI2), endothelin-1 (ET1), and thromboxane A2 (TXA2), were measured in rat blood. The impact of sinapine on vascular endothelial cell (A10) calcium and potassium channels was assessed using the patch-clamp technique. One-time or long-term administration of sinapine significantly reduced the rats’ systolic blood pressure (SBP), diastolic pressure (DBP), and mean blood pressure (MBP). Sinapine also decreased the levels of Ang II and ALD. Furthermore, sinapine effectively inhibited ACE activation, increased NO levels, and blocked L-type calcium channels. Sinapine has an antihypertensive function and achieves this process through multiple targets.https://doi.org/10.1038/s41598-025-88926-0SinapineRapeseed meal2K1CAntihypertensive effectRAASCalcium channel |
| spellingShingle | Gaoyuan Yang Lin Zhu Yu Wang Yang Yu Xiaoguang Liu Jingbo Xia Yunjie Yang Huiguo Wang Baomin Feng Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats Scientific Reports Sinapine Rapeseed meal 2K1C Antihypertensive effect RAAS Calcium channel |
| title | Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats |
| title_full | Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats |
| title_fullStr | Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats |
| title_full_unstemmed | Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats |
| title_short | Antihypertensive effect of sinapine extracted from rapeseed meal in 2K1C hypertensive rats |
| title_sort | antihypertensive effect of sinapine extracted from rapeseed meal in 2k1c hypertensive rats |
| topic | Sinapine Rapeseed meal 2K1C Antihypertensive effect RAAS Calcium channel |
| url | https://doi.org/10.1038/s41598-025-88926-0 |
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