Nonlinear relationship between body fat percentage and NAFLD mediated by METS-IR: threshold effects and subgroup differences

Nonlinear relationship between body fat percentage and NAFLD mediated by METS-IR: threshold effects and subgroup differences

Abstract The mechanism linking body fat percentage (BFR) and non-alcoholic fatty liver disease (NAFLD) remains unclear. This study investigated whether the metabolic score for insulin resistance (METS-IR) mediates this relationship and examined threshold effects and population heterogeneity. In this...

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Bibliographic Details
Main Authors: Haiyuan Zhao, Yongxin Fang, Jun Zhao, Nianzhao Yang, Yang Li, Fubao Liu, Xiaopeng Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Non-alcoholic fatty liver disease (NAFLD)
Body fat percentage (BFR)
Metabolic score for insulin resistance (METS-IR)
Insulin resistance
Mediation analysis
Threshold effect
Online Access:https://doi.org/10.1038/s41598-025-10765-w
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