Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
Abstract In recent years, magnolol (MG), a natural active compound of polyphenolic nature, has garnered significant interest for its anti-cancer effects. Numerous studies conducted on cell lines and animal models have indicated a positive impact of administering drugs or semi-synthesized products de...
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| Format: | Article |
| Language: | English |
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Springer
2025-05-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02409-2 |
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| author | Asmita Rayamajhi Nisha Gyawali Deepa Karki Luis E. Pérez-Caltzontzin Sheila I. Peña-Corona Hernán Cortés Achyut Adhikari Gerardo Leyva-Gómez Yadav Uprety Solomon Habtemariam Lashyn Kiyekbayeva Javad Sharifi-Rad |
| author_facet | Asmita Rayamajhi Nisha Gyawali Deepa Karki Luis E. Pérez-Caltzontzin Sheila I. Peña-Corona Hernán Cortés Achyut Adhikari Gerardo Leyva-Gómez Yadav Uprety Solomon Habtemariam Lashyn Kiyekbayeva Javad Sharifi-Rad |
| author_sort | Asmita Rayamajhi |
| collection | DOAJ |
| description | Abstract In recent years, magnolol (MG), a natural active compound of polyphenolic nature, has garnered significant interest for its anti-cancer effects. Numerous studies conducted on cell lines and animal models have indicated a positive impact of administering drugs or semi-synthesized products derived from MG, including a decreased incidence of various cancers. This review aims to illustrate the underlying cellular and molecular basis of its actions. The article includes in-depth explanations of phytochemistry, semi-synthetic derivatives, bioavailability, pharmacokinetics, preclinical research, anti-tumor mechanisms, human clinical studies, toxicity, side effects, and safety. It also demonstrates that, in contrast to the wealth of synthetic medications, MG is highly effective against bladder, colon, gastric, skin, liver, lung, gallbladder, and prostate cancers. The findings of this review indicate that MG is a promising candidate as an anti-tumor agent, and future research should focus on developing new semi-synthetic derivative compounds with potential anti-tumor properties. |
| format | Article |
| id | doaj-art-e4bdbcd61bad4ca88032a79e43cb8410 |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-e4bdbcd61bad4ca88032a79e43cb84102025-08-20T03:10:32ZengSpringerDiscover Oncology2730-60112025-05-0116112010.1007/s12672-025-02409-2Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potentialAsmita Rayamajhi0Nisha Gyawali1Deepa Karki2Luis E. Pérez-Caltzontzin3Sheila I. Peña-Corona4Hernán Cortés5Achyut Adhikari6Gerardo Leyva-Gómez7Yadav Uprety8Solomon Habtemariam9Lashyn Kiyekbayeva10Javad Sharifi-Rad11Central Department of Chemistry, Tribhuvan UniversityCentral Department of Chemistry, Tribhuvan UniversityCentral Department of Chemistry, Tribhuvan UniversityDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de MéxicoDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de MéxicoLaboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra IbarraCentral Department of Chemistry, Tribhuvan UniversityDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de MéxicoCentral Department of Botany, Tribhuvan UniversityPharmacognosy Research & Herbal Analysis Services UKDepartment of Pharmaceutical Technology, Pharmaceutical School, Asfendiyarov Kazakh National Medical UniversityUniversidad Espíritu SantoAbstract In recent years, magnolol (MG), a natural active compound of polyphenolic nature, has garnered significant interest for its anti-cancer effects. Numerous studies conducted on cell lines and animal models have indicated a positive impact of administering drugs or semi-synthesized products derived from MG, including a decreased incidence of various cancers. This review aims to illustrate the underlying cellular and molecular basis of its actions. The article includes in-depth explanations of phytochemistry, semi-synthetic derivatives, bioavailability, pharmacokinetics, preclinical research, anti-tumor mechanisms, human clinical studies, toxicity, side effects, and safety. It also demonstrates that, in contrast to the wealth of synthetic medications, MG is highly effective against bladder, colon, gastric, skin, liver, lung, gallbladder, and prostate cancers. The findings of this review indicate that MG is a promising candidate as an anti-tumor agent, and future research should focus on developing new semi-synthetic derivative compounds with potential anti-tumor properties.https://doi.org/10.1007/s12672-025-02409-2Natural polyphenolic compoundMagnololCancer cell growth inhibitionLow water solubilityMagnolia speciesSemi-synthetic derivatives |
| spellingShingle | Asmita Rayamajhi Nisha Gyawali Deepa Karki Luis E. Pérez-Caltzontzin Sheila I. Peña-Corona Hernán Cortés Achyut Adhikari Gerardo Leyva-Gómez Yadav Uprety Solomon Habtemariam Lashyn Kiyekbayeva Javad Sharifi-Rad Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential Discover Oncology Natural polyphenolic compound Magnolol Cancer cell growth inhibition Low water solubility Magnolia species Semi-synthetic derivatives |
| title | Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential |
| title_full | Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential |
| title_fullStr | Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential |
| title_full_unstemmed | Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential |
| title_short | Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential |
| title_sort | magnolol and its semi synthetic derivatives a comprehensive review of anti cancer mechanisms pharmacokinetics and future therapeutic potential |
| topic | Natural polyphenolic compound Magnolol Cancer cell growth inhibition Low water solubility Magnolia species Semi-synthetic derivatives |
| url | https://doi.org/10.1007/s12672-025-02409-2 |
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