The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan

The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan

<i>Candida</i> infections are a global health concern, increasingly complicated by rising antimicrobial resistance (AMR). This study analyzed the prevalence and AMR patterns of circulating <i>Candida</i> species in Amman, Jordan, using electronic records from a tertiary teach...

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Main Authors: Anas H. Abu-Humaidan, Areen Alshdaifat, Dima Awajan, Mohammad Abu-Hmidan, Abeer Alshdifat, Hanan Hasan, Fatima M. Ahmad, Nader Alaridah, Amal Irshaid, Dina Yamin
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Journal of Fungi
Subjects:
<i>Candida</i>
<i>albicans</i>
<i>tropicalis</i>
<i>Nakaseomyces glabratus</i>
<i>Pichia kudriavzevii</i>
registry
Online Access:https://www.mdpi.com/2309-608X/11/2/87
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Summary:<i>Candida</i> infections are a global health concern, increasingly complicated by rising antimicrobial resistance (AMR). This study analyzed the prevalence and AMR patterns of circulating <i>Candida</i> species in Amman, Jordan, using electronic records from a tertiary teaching hospital’s microbiology lab (from 2017 to 2022). Complete records of <i>Candida</i> isolates (n = 2673) were assessed by sample type, species, and AMR. Among positive blood samples, <i>C. albicans</i> accounted for the majority (38.7%), followed by <i>C. tropicalis</i> (19.0%), <i>C. parapsilosis</i> (18.3%), <i>Nakaseomyces glabratus</i> (14.6%), and <i>Pichia kudriavzevii</i> (9.5%). Non-<i>albicans</i> species demonstrated higher resistance to Caspofungin, notably <i>P. kudriavzevii</i> (23.1%), <i>N. glabratus</i> (30.0%), and <i>C. parapsilosis</i> (32.0%), compared to <i>C. albicans</i> (1.9%). In high vaginal swabs, <i>C. albicans</i> was most prevalent (63.7%), with <i>N. glabratus</i> also notable (28.6%); Fluconazole resistance in <i>C. albicans</i> remained low (2.0%). Across all pooled isolates, AMR was similar between inpatients and outpatients, except for Micafungin, where inpatient resistance was significantly higher. In conclusion, non-<i>albicans</i> species predominated in blood infections and demonstrated pronounced AMR. Micafungin resistance was notably higher among inpatients. Variations in <i>Candida</i> species and AMR by sample type suggest that aggregating samples in registry studies may obscure critical patterns.
ISSN:2309-608X

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