Drug-Induced Hematologic Syndromes
Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes. Meth...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2009/495863 |
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| _version_ | 1849435068884320256 |
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| author | David M. Mintzer Shira N. Billet Lauren Chmielewski |
| author_facet | David M. Mintzer Shira N. Billet Lauren Chmielewski |
| author_sort | David M. Mintzer |
| collection | DOAJ |
| description | Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes.
Methods. Medline literature on drug-induced hematologic syndromes was reviewed. Most reports and reviews focus on individual drugs or cytopenias. Results. Drug-induced syndromes include hemolytic anemias, methemoglobinemia, red cell aplasia, sideroblastic anemia, megaloblastic anemia, polycythemia, aplastic anemia, leukocytosis, neutropenia, eosinophilia, immune thrombocytopenia, microangiopathic syndromes, hypercoagulability, hypoprothrombinemia, circulating anticoagulants, myelodysplasia, and acute leukemia. Some of the classic drugs known to cause hematologic abnormalities have been replaced by newer drugs, including biologics, accompanied by their own syndromes and unintended side effects. Conclusions. Drugs can induce toxicities spanning many hematologic syndromes, mediated by a variety of mechanisms. Physicians need to be alert to the potential for iatrogenic drug-induced hematologic complications. |
| format | Article |
| id | doaj-art-e4ba959878fc4a31beada32c1606b3a5 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-e4ba959878fc4a31beada32c1606b3a52025-08-20T03:26:25ZengWileyAdvances in Hematology1687-91041687-91122009-01-01200910.1155/2009/495863495863Drug-Induced Hematologic SyndromesDavid M. Mintzer0Shira N. Billet1Lauren Chmielewski2Section of Hematology and Medical Oncology, Pennsylvania Hospital, Philadelphia, PA 19106, USASection of Hematology and Medical Oncology, Pennsylvania Hospital, Philadelphia, PA 19106, USASection of Hematology and Medical Oncology, Pennsylvania Hospital, Philadelphia, PA 19106, USAObjective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes. Methods. Medline literature on drug-induced hematologic syndromes was reviewed. Most reports and reviews focus on individual drugs or cytopenias. Results. Drug-induced syndromes include hemolytic anemias, methemoglobinemia, red cell aplasia, sideroblastic anemia, megaloblastic anemia, polycythemia, aplastic anemia, leukocytosis, neutropenia, eosinophilia, immune thrombocytopenia, microangiopathic syndromes, hypercoagulability, hypoprothrombinemia, circulating anticoagulants, myelodysplasia, and acute leukemia. Some of the classic drugs known to cause hematologic abnormalities have been replaced by newer drugs, including biologics, accompanied by their own syndromes and unintended side effects. Conclusions. Drugs can induce toxicities spanning many hematologic syndromes, mediated by a variety of mechanisms. Physicians need to be alert to the potential for iatrogenic drug-induced hematologic complications.http://dx.doi.org/10.1155/2009/495863 |
| spellingShingle | David M. Mintzer Shira N. Billet Lauren Chmielewski Drug-Induced Hematologic Syndromes Advances in Hematology |
| title | Drug-Induced Hematologic Syndromes |
| title_full | Drug-Induced Hematologic Syndromes |
| title_fullStr | Drug-Induced Hematologic Syndromes |
| title_full_unstemmed | Drug-Induced Hematologic Syndromes |
| title_short | Drug-Induced Hematologic Syndromes |
| title_sort | drug induced hematologic syndromes |
| url | http://dx.doi.org/10.1155/2009/495863 |
| work_keys_str_mv | AT davidmmintzer druginducedhematologicsyndromes AT shiranbillet druginducedhematologicsyndromes AT laurenchmielewski druginducedhematologicsyndromes |