Exosome-Loaded Bioscaffolds for Spinal Cord Injuries: A Review
Exosomes are naturally occurring cellular products released by various cell types in the body. Their composition is similar to that of human tissues, which reduces the risk of immune rejection. As critical mediators of intercellular communication, exosomes transmit signals and information that regul...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/sci/8841129 |
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| _version_ | 1850036112388521984 |
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| author | Ruilin Chen Jian Zheng Jie Hao Yang Yang Shaohu Xu Feiyu Zhang Feng Zhang Yu Yao |
| author_facet | Ruilin Chen Jian Zheng Jie Hao Yang Yang Shaohu Xu Feiyu Zhang Feng Zhang Yu Yao |
| author_sort | Ruilin Chen |
| collection | DOAJ |
| description | Exosomes are naturally occurring cellular products released by various cell types in the body. Their composition is similar to that of human tissues, which reduces the risk of immune rejection. As critical mediators of intercellular communication, exosomes transmit signals and information that regulate the physiological states of surrounding tissues. Depending on their cellular origin and molecular content, exosomes can either promote nerve regeneration and functional recovery at the site of spinal cord injury (SCI) or exacerbate the local injury microenvironment. However, as a cellular product, the composition and function of exosomes are affected by the type and state of the cells from which they originate, and thus, there may be specificity problems in treatment, such as the possible instability of the therapeutic effect, et cetera. Moreover, exosomes need to be further optimized in terms of their delivery and release strategies in order to improve the duration and stability of the therapeutic effect. Thus, a single therapy approach is often insufficient to effectively support nerve repair following SCI. Numerous studies have demonstrated that encapsulating exosomes within biomaterial scaffolds enhances their delivery and retention at the injury site, thereby improving their viability. This paper reviews the latest research on stem cell-derived exosomes and biomaterials in the context of SCI. It further explores the combined application of exosomes and biomaterial scaffolds in SCI treatment, while also addressing the associated challenges and future prospects. |
| format | Article |
| id | doaj-art-e4b9419d28fa433fb11fe91335d2a8e8 |
| institution | DOAJ |
| issn | 1687-9678 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e4b9419d28fa433fb11fe91335d2a8e82025-08-20T02:57:17ZengWileyStem Cells International1687-96782025-01-01202510.1155/sci/8841129Exosome-Loaded Bioscaffolds for Spinal Cord Injuries: A ReviewRuilin Chen0Jian Zheng1Jie Hao2Yang Yang3Shaohu Xu4Feiyu Zhang5Feng Zhang6Yu Yao7School of MedicineSchool of MedicineDepartment of OrthopedicsDepartment of Trauma CenterSchool of MedicineSchool of MedicineDepartment of OrthopedicsDepartment of OrthopedicsExosomes are naturally occurring cellular products released by various cell types in the body. Their composition is similar to that of human tissues, which reduces the risk of immune rejection. As critical mediators of intercellular communication, exosomes transmit signals and information that regulate the physiological states of surrounding tissues. Depending on their cellular origin and molecular content, exosomes can either promote nerve regeneration and functional recovery at the site of spinal cord injury (SCI) or exacerbate the local injury microenvironment. However, as a cellular product, the composition and function of exosomes are affected by the type and state of the cells from which they originate, and thus, there may be specificity problems in treatment, such as the possible instability of the therapeutic effect, et cetera. Moreover, exosomes need to be further optimized in terms of their delivery and release strategies in order to improve the duration and stability of the therapeutic effect. Thus, a single therapy approach is often insufficient to effectively support nerve repair following SCI. Numerous studies have demonstrated that encapsulating exosomes within biomaterial scaffolds enhances their delivery and retention at the injury site, thereby improving their viability. This paper reviews the latest research on stem cell-derived exosomes and biomaterials in the context of SCI. It further explores the combined application of exosomes and biomaterial scaffolds in SCI treatment, while also addressing the associated challenges and future prospects.http://dx.doi.org/10.1155/sci/8841129 |
| spellingShingle | Ruilin Chen Jian Zheng Jie Hao Yang Yang Shaohu Xu Feiyu Zhang Feng Zhang Yu Yao Exosome-Loaded Bioscaffolds for Spinal Cord Injuries: A Review Stem Cells International |
| title | Exosome-Loaded Bioscaffolds for Spinal Cord Injuries: A Review |
| title_full | Exosome-Loaded Bioscaffolds for Spinal Cord Injuries: A Review |
| title_fullStr | Exosome-Loaded Bioscaffolds for Spinal Cord Injuries: A Review |
| title_full_unstemmed | Exosome-Loaded Bioscaffolds for Spinal Cord Injuries: A Review |
| title_short | Exosome-Loaded Bioscaffolds for Spinal Cord Injuries: A Review |
| title_sort | exosome loaded bioscaffolds for spinal cord injuries a review |
| url | http://dx.doi.org/10.1155/sci/8841129 |
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