Effect of micro-architectural design and polymer infiltration on mechanical properties and fatigue life of strut- and sheet-based lattice bone scaffolds

Lattice structures are widely used in biomedical engineering, primarily due to their exceptional properties which results from their unique microstructural features. The variability in geometric parameters of the lattice microstructure, enables property adjustment to meet different needs. In this pa...

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Main Authors: S.Kazemivand Niar, G. Nikaein, M.H. Sadeghi, B. Vrancken, B. van Hooreweder, M.J. Mirzaali
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Materials & Design
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Online Access:http://www.sciencedirect.com/science/article/pii/S0264127525006379
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author S.Kazemivand Niar
G. Nikaein
M.H. Sadeghi
B. Vrancken
B. van Hooreweder
M.J. Mirzaali
author_facet S.Kazemivand Niar
G. Nikaein
M.H. Sadeghi
B. Vrancken
B. van Hooreweder
M.J. Mirzaali
author_sort S.Kazemivand Niar
collection DOAJ
description Lattice structures are widely used in biomedical engineering, primarily due to their exceptional properties which results from their unique microstructural features. The variability in geometric parameters of the lattice microstructure, enables property adjustment to meet different needs. In this paper, the mechanical properties of lattice structures are investigated with respect to unit cell type, porosity, and presence of an infiltrated resin, which simulates bone tissue within the scaffold. Digital image correlation technique was employed to assess deformation modes in in-filled structures. Three different architectures, including Diamond, FCC and Gyroid with three distinct relative densities of 15 %, 25 %, and 35 % have been designed and fabricated using Ti-6Al-4 V biomaterial. Results showed that the Gyroid lattice structures demonstrated superior mechanical properties compared to Diamond and FCC lattices under quasi-static compression tests. Distinct failure behavior was also observed across the structures. At higher relative densities, Diamond and FCC lattices formed 45° macro-cracks, whereas Gyroid samples compressed severely without macro-cracks. Furthermore, in-filled structures, demonstrated up to 1.3 times higher strength compared to their as-built counterparts. Notably, a unified master curve was developed to facilitate the prediction of fatigue lives of all geometries. These findings support the development of implants with enhanced longevity and performance.
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spelling doaj-art-e4b766036a284bb5b2bdd345ddff7ae62025-08-20T02:10:01ZengElsevierMaterials & Design0264-12752025-07-0125511421710.1016/j.matdes.2025.114217Effect of micro-architectural design and polymer infiltration on mechanical properties and fatigue life of strut- and sheet-based lattice bone scaffoldsS.Kazemivand Niar0G. Nikaein1M.H. Sadeghi2B. Vrancken3B. van Hooreweder4M.J. Mirzaali5Faculty of Mechanical Engineering, Tarbiat Modares University, Tehran, IranFaculty of Mechanical Engineering, Tarbiat Modares University, Tehran, IranFaculty of Mechanical Engineering, Tarbiat Modares University, Tehran, Iran; Corresponding author.Deparment of Mechanical Engineering, Katholieke Universiteit Leuven, Leuven, BelgiumDeparment of Mechanical Engineering, Katholieke Universiteit Leuven, Leuven, BelgiumDepartment of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology (TU Delft), Mekelweg 2, 2628 CD Delft, the NetherlandsLattice structures are widely used in biomedical engineering, primarily due to their exceptional properties which results from their unique microstructural features. The variability in geometric parameters of the lattice microstructure, enables property adjustment to meet different needs. In this paper, the mechanical properties of lattice structures are investigated with respect to unit cell type, porosity, and presence of an infiltrated resin, which simulates bone tissue within the scaffold. Digital image correlation technique was employed to assess deformation modes in in-filled structures. Three different architectures, including Diamond, FCC and Gyroid with three distinct relative densities of 15 %, 25 %, and 35 % have been designed and fabricated using Ti-6Al-4 V biomaterial. Results showed that the Gyroid lattice structures demonstrated superior mechanical properties compared to Diamond and FCC lattices under quasi-static compression tests. Distinct failure behavior was also observed across the structures. At higher relative densities, Diamond and FCC lattices formed 45° macro-cracks, whereas Gyroid samples compressed severely without macro-cracks. Furthermore, in-filled structures, demonstrated up to 1.3 times higher strength compared to their as-built counterparts. Notably, a unified master curve was developed to facilitate the prediction of fatigue lives of all geometries. These findings support the development of implants with enhanced longevity and performance.http://www.sciencedirect.com/science/article/pii/S0264127525006379Additive manufacturingMeta-biomaterialsStrut-based latticesSheet-based latticesFatigue lifeLaser Powder Bed Fusion (L-PBF)
spellingShingle S.Kazemivand Niar
G. Nikaein
M.H. Sadeghi
B. Vrancken
B. van Hooreweder
M.J. Mirzaali
Effect of micro-architectural design and polymer infiltration on mechanical properties and fatigue life of strut- and sheet-based lattice bone scaffolds
Materials & Design
Additive manufacturing
Meta-biomaterials
Strut-based lattices
Sheet-based lattices
Fatigue life
Laser Powder Bed Fusion (L-PBF)
title Effect of micro-architectural design and polymer infiltration on mechanical properties and fatigue life of strut- and sheet-based lattice bone scaffolds
title_full Effect of micro-architectural design and polymer infiltration on mechanical properties and fatigue life of strut- and sheet-based lattice bone scaffolds
title_fullStr Effect of micro-architectural design and polymer infiltration on mechanical properties and fatigue life of strut- and sheet-based lattice bone scaffolds
title_full_unstemmed Effect of micro-architectural design and polymer infiltration on mechanical properties and fatigue life of strut- and sheet-based lattice bone scaffolds
title_short Effect of micro-architectural design and polymer infiltration on mechanical properties and fatigue life of strut- and sheet-based lattice bone scaffolds
title_sort effect of micro architectural design and polymer infiltration on mechanical properties and fatigue life of strut and sheet based lattice bone scaffolds
topic Additive manufacturing
Meta-biomaterials
Strut-based lattices
Sheet-based lattices
Fatigue life
Laser Powder Bed Fusion (L-PBF)
url http://www.sciencedirect.com/science/article/pii/S0264127525006379
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