Short-term high-fat diet feeding plus acute ethanol binge induced acute liver injury in mice via oxidative stress, inflammation and pyroptosis

Short-term high-fat diet feeding plus acute ethanol binge induced acute liver injury in mice via oxidative stress, inflammation and pyroptosis

BackgroundEthanol binge and obesity are the key risk factors for alcohol-related liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD), respectively. The human beings have a habit of drinking alcohol and consuming high calorie foods, these two factors often coexist, and thus contributing...

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Main Authors: Yao Deng, Xinling Chen, Wenhai Guo, Yun Chen, Luyao Xu, Wenting Suo, Wei Liu, Jiaying Dai, Kangrong Wang, Qiuling Li, Chengqin Lu, Min Dai, Jiean Xu, Jinwen Xu, Hequan Zhu, Zaoyuan Kuang, Yaxing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
high-fat diet feeding
acute ethanol binge
oxidative stress
caspase-1
caspase-8
caspase-11
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1602280/full
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