A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation
This randomized controlled trial investigates the optimal dosing for post-stroke rehabilitation using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). Previous studies demonstrated improvements in cognitive and motor functions with specific inte...
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Elsevier
2025-06-01
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| Series: | MethodsX |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215016125000524 |
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| author | Ayesha Juhi Manul Das Dinesh Bhatia Suman Dhaka Rajesh Kumar Deepak Kumar Shreya Sharma Pritam Kumar Chaudhary Chanchal Goyal Md Asif Khan Himel Mondal |
| author_facet | Ayesha Juhi Manul Das Dinesh Bhatia Suman Dhaka Rajesh Kumar Deepak Kumar Shreya Sharma Pritam Kumar Chaudhary Chanchal Goyal Md Asif Khan Himel Mondal |
| author_sort | Ayesha Juhi |
| collection | DOAJ |
| description | This randomized controlled trial investigates the optimal dosing for post-stroke rehabilitation using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). Previous studies demonstrated improvements in cognitive and motor functions with specific intensities of rTMS and tDCS, but this trial explores various frequencies and currents to optimize therapeutic outcomes. A total of 128 post-stroke patients (within 1–6 months of stroke) with paraplegia or hemiplegia are recruited. Patients are divided into four groups for both rTMS (n = 49) and tDCS (n = 49): three groups with different stimulation intensities (1 Hz, 5 Hz, 10 Hz for rTMS; 0.5 mA, 1 mA, 2 mA for tDCS) and a sham control group. Along with this, there is a standard therapy group (n = 30) as control. Participants receive 20 min sessions, five days a week, over six weeks. Cognitive and motor assessments are conducted at 4 weeks, 6 weeks, and 6 months to measure short-term and sustained effects. • Hemodynamically stable post-stroke patients randomized in four groups in rTMS and tDCS each and their baseline cognitive and motor function assessed • Application of the two types of therapy for 6 weeks • Checking improvement of cognitive and motor function and compare the improvement among subgroups of recipient of various frequencies and currents |
| format | Article |
| id | doaj-art-e4acf5631f3e4471b1c813ab39d785db |
| institution | Kabale University |
| issn | 2215-0161 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | MethodsX |
| spelling | doaj-art-e4acf5631f3e4471b1c813ab39d785db2025-02-12T05:31:10ZengElsevierMethodsX2215-01612025-06-0114103209A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitationAyesha Juhi0Manul Das1Dinesh Bhatia2Suman Dhaka3Rajesh Kumar4Deepak Kumar5Shreya Sharma6Pritam Kumar Chaudhary7Chanchal Goyal8Md Asif Khan9Himel Mondal10Department of Physiology, All India Institute of Medical Sciences, Deoghar, Jharkhand, IndiaClinical Research Centre for Neuromodulation in Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, IndiaDepartment of Biomedical Engineering, North-Eastern Hill University, Shillong, Meghalaya, IndiaSchool of Liberal Arts and Center for Brain Science and Application (SAIDE), Indian Institute of Technology, Jodhpur, IndiaDepartment of Internal Medicine, All India Institute of Medical Sciences, Deoghar, Jharkhand, IndiaDepartment of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, Deoghar, Jharkhand, IndiaNeuromodulation Laboratory, Department of Physiology, All India Institute of Medical Sciences, Deoghar, Jharkhand, IndiaNeuromodulation Laboratory, Department of Physiology, All India Institute of Medical Sciences, Deoghar, Jharkhand, IndiaCentre for Evidence for Guidelines, Indian Council of Medical Research, New Delhi, IndiaDescriptive Research Division, Indian Council of Medical Research, New Delhi, IndiaDepartment of Physiology, All India Institute of Medical Sciences, Deoghar, Jharkhand, India; Corresponding author.This randomized controlled trial investigates the optimal dosing for post-stroke rehabilitation using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). Previous studies demonstrated improvements in cognitive and motor functions with specific intensities of rTMS and tDCS, but this trial explores various frequencies and currents to optimize therapeutic outcomes. A total of 128 post-stroke patients (within 1–6 months of stroke) with paraplegia or hemiplegia are recruited. Patients are divided into four groups for both rTMS (n = 49) and tDCS (n = 49): three groups with different stimulation intensities (1 Hz, 5 Hz, 10 Hz for rTMS; 0.5 mA, 1 mA, 2 mA for tDCS) and a sham control group. Along with this, there is a standard therapy group (n = 30) as control. Participants receive 20 min sessions, five days a week, over six weeks. Cognitive and motor assessments are conducted at 4 weeks, 6 weeks, and 6 months to measure short-term and sustained effects. • Hemodynamically stable post-stroke patients randomized in four groups in rTMS and tDCS each and their baseline cognitive and motor function assessed • Application of the two types of therapy for 6 weeks • Checking improvement of cognitive and motor function and compare the improvement among subgroups of recipient of various frequencies and currentshttp://www.sciencedirect.com/science/article/pii/S2215016125000524Neuromodulation |
| spellingShingle | Ayesha Juhi Manul Das Dinesh Bhatia Suman Dhaka Rajesh Kumar Deepak Kumar Shreya Sharma Pritam Kumar Chaudhary Chanchal Goyal Md Asif Khan Himel Mondal A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation MethodsX Neuromodulation |
| title | A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation |
| title_full | A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation |
| title_fullStr | A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation |
| title_full_unstemmed | A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation |
| title_short | A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation |
| title_sort | protocol to optimize non invasive brain stimulation for post stroke rehabilitation |
| topic | Neuromodulation |
| url | http://www.sciencedirect.com/science/article/pii/S2215016125000524 |
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