Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial
Aim. To identify the features of myocardial remodeling after implantation of a dispersed allogenic biomaterial (DAB) in the subacute stage of experimental infarction and determine the role of decay products in the formation of regenerate.Material and methods. Male rats in the control group (n=30) 5...
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«FIRMA «SILICEA» LLC
2019-08-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3350 |
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| author | A. I. Lebedeva S. A. Afanasyev D. S. Kondratyeva E. M. Gareev S. A. Muslimov S. V. Popov |
| author_facet | A. I. Lebedeva S. A. Afanasyev D. S. Kondratyeva E. M. Gareev S. A. Muslimov S. V. Popov |
| author_sort | A. I. Lebedeva |
| collection | DOAJ |
| description | Aim. To identify the features of myocardial remodeling after implantation of a dispersed allogenic biomaterial (DAB) in the subacute stage of experimental infarction and determine the role of decay products in the formation of regenerate.Material and methods. Male rats in the control group (n=30) 5 days after coronary occlusion received physiological saline (intramyocardially), in the experimental group (n=30) — 3 mg of DAB. Myocardial tissues were examined after 7 14, 50 days from the beginning of the experiment using histological, immunohistochemical and statistical methods.Results. In the experimental group, the cicatrix area was reduced by 1,66 times. The products of DAB biodegradation were collagen, sulfated (dermatan- and keratan sulfate), as well as non-sulfated (hyaluronic acid) glycosaminoglycans. Used DAB served as a promoter of the early proliferative phase of inflammation and had an anti-inflammatory effect. DAB particles were a chemoattractant of stem and progenitor myocardial cells in the subacute stage of myocardial infarction. It contributed to their differentiation and integration into the tissue.Conclusion. The products of biodegradation of allogeneic biomaterial, administered intramyocardially in the subacute stage of infarction, contribute to the formation of muscular-connective tissue regenerate and effectively prevent its cicatricial devolution. |
| format | Article |
| id | doaj-art-e4aa786c3078480fb1e2ac96a8f47910 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2019-08-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-e4aa786c3078480fb1e2ac96a8f479102025-08-20T03:43:36Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202019-08-0107687410.15829/1560-4071-2019-7-68-742689Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterialA. I. Lebedeva0S. A. Afanasyev1D. S. Kondratyeva2E. M. Gareev3S. A. Muslimov4S. V. Popov5All-Russian Eye and Plastic Surgery Center; Bashkir State Medical UniversityResearch Institute of Cardiology, National Research Medical CenterResearch Institute of Cardiology, National Research Medical CenterAll-Russian Eye and Plastic Surgery CenterAll-Russian Eye and Plastic Surgery Center; Bashkir State Medical UniversityResearch Institute of Cardiology, National Research Medical CenterAim. To identify the features of myocardial remodeling after implantation of a dispersed allogenic biomaterial (DAB) in the subacute stage of experimental infarction and determine the role of decay products in the formation of regenerate.Material and methods. Male rats in the control group (n=30) 5 days after coronary occlusion received physiological saline (intramyocardially), in the experimental group (n=30) — 3 mg of DAB. Myocardial tissues were examined after 7 14, 50 days from the beginning of the experiment using histological, immunohistochemical and statistical methods.Results. In the experimental group, the cicatrix area was reduced by 1,66 times. The products of DAB biodegradation were collagen, sulfated (dermatan- and keratan sulfate), as well as non-sulfated (hyaluronic acid) glycosaminoglycans. Used DAB served as a promoter of the early proliferative phase of inflammation and had an anti-inflammatory effect. DAB particles were a chemoattractant of stem and progenitor myocardial cells in the subacute stage of myocardial infarction. It contributed to their differentiation and integration into the tissue.Conclusion. The products of biodegradation of allogeneic biomaterial, administered intramyocardially in the subacute stage of infarction, contribute to the formation of muscular-connective tissue regenerate and effectively prevent its cicatricial devolution.https://russjcardiol.elpub.ru/jour/article/view/3350allogenic biomaterialmyocardial regenerationglycosaminoglycans |
| spellingShingle | A. I. Lebedeva S. A. Afanasyev D. S. Kondratyeva E. M. Gareev S. A. Muslimov S. V. Popov Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial Российский кардиологический журнал allogenic biomaterial myocardial regeneration glycosaminoglycans |
| title | Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial |
| title_full | Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial |
| title_fullStr | Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial |
| title_full_unstemmed | Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial |
| title_short | Correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial |
| title_sort | correction of cicatricial changes in subacute stage of myocardial infarction with using of dispersed allogenic biomaterial |
| topic | allogenic biomaterial myocardial regeneration glycosaminoglycans |
| url | https://russjcardiol.elpub.ru/jour/article/view/3350 |
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