Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups
In order to prevent children morbidity and mortality 116 children aged from 6 months to 5 years from 2 risk groups (1 — with bronchial-pulmonary dysplasia and 2 — with congenital heart defects) were vaccinated with pneumococcal 7-valent conjugated vaccine in 2011 at the expense of municipal budget....
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2013-03-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/356 |
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| author | O. A. Beletskaya Yu.N. Gorbatykh A. N. Shmakov N. Yu. Ishalina T. Yu. Ivleva N. V. Kukhtinova |
| author_facet | O. A. Beletskaya Yu.N. Gorbatykh A. N. Shmakov N. Yu. Ishalina T. Yu. Ivleva N. V. Kukhtinova |
| author_sort | O. A. Beletskaya |
| collection | DOAJ |
| description | In order to prevent children morbidity and mortality 116 children aged from 6 months to 5 years from 2 risk groups (1 — with bronchial-pulmonary dysplasia and 2 — with congenital heart defects) were vaccinated with pneumococcal 7-valent conjugated vaccine in 2011 at the expense of municipal budget. Among 116 children from both groups 16 (14%) have had community-acquired pneumonia, which is 22 times higher than in general children population in this region. Dynamic 1-year follow-up showed significant decrease of community-acquired pneumonia prevalence in risk groups: from 16/116 (14%) to 1/75 (1%) (p =0,006). There were no cases of invasive pneumococcal infections among vaccinated children and in 87,5% of them the general morbidity decreased. The frequency of moderate general post-vaccinal reactions was 1,8%, topical reactions — 0,9%. There were no other side effects during post-vaccinal period. Thereafter, the vaccination against pneumococcal infection performed in Novosibirsk in children with risk of fatal complications showed high efficacy and safety of the used vaccine. |
| format | Article |
| id | doaj-art-e4a52fe9a1a64ea2885a2b23130d9cd8 |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2013-03-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-e4a52fe9a1a64ea2885a2b23130d9cd82025-08-20T03:57:26Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352013-03-0112212312610.15690/vsp.v12i2.630356Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groupsO. A. Beletskaya0Yu.N. Gorbatykh1A. N. Shmakov2N. Yu. Ishalina3T. Yu. Ivleva4N. V. Kukhtinova5Department of Obstetrics and Organization of Specialized Medical Care to Children of the Novosibirsk City Administration, Russian FederationE.N. Meshalkin Novosibirsk Scientific Research Institute of Blood Circulation Disorders,Novosibirsk State Medical UniversityGeras’kov Children Municipal Clinical Hospital №4, NovosibirskMunicipal Children Out-Patient Clinic №2, NovosibirskNovosibirsk State Medical UniversityIn order to prevent children morbidity and mortality 116 children aged from 6 months to 5 years from 2 risk groups (1 — with bronchial-pulmonary dysplasia and 2 — with congenital heart defects) were vaccinated with pneumococcal 7-valent conjugated vaccine in 2011 at the expense of municipal budget. Among 116 children from both groups 16 (14%) have had community-acquired pneumonia, which is 22 times higher than in general children population in this region. Dynamic 1-year follow-up showed significant decrease of community-acquired pneumonia prevalence in risk groups: from 16/116 (14%) to 1/75 (1%) (p =0,006). There were no cases of invasive pneumococcal infections among vaccinated children and in 87,5% of them the general morbidity decreased. The frequency of moderate general post-vaccinal reactions was 1,8%, topical reactions — 0,9%. There were no other side effects during post-vaccinal period. Thereafter, the vaccination against pneumococcal infection performed in Novosibirsk in children with risk of fatal complications showed high efficacy and safety of the used vaccine.https://vsp.spr-journal.ru/jour/article/view/356childrenpneumococcal vaccinebronchial-pulmonary dysplasiacongenital heart defect |
| spellingShingle | O. A. Beletskaya Yu.N. Gorbatykh A. N. Shmakov N. Yu. Ishalina T. Yu. Ivleva N. V. Kukhtinova Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups Вопросы современной педиатрии children pneumococcal vaccine bronchial-pulmonary dysplasia congenital heart defect |
| title | Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups |
| title_full | Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups |
| title_fullStr | Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups |
| title_full_unstemmed | Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups |
| title_short | Efficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groups |
| title_sort | efficacy of usage of pneumococcal 7 valent vaccine in prophylaxis of pneumococcal infection in novosibirsk children from risk groups |
| topic | children pneumococcal vaccine bronchial-pulmonary dysplasia congenital heart defect |
| url | https://vsp.spr-journal.ru/jour/article/view/356 |
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