Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip.
Bone morphogenetic proteins (BMPs) have been hypothesized to specify distinct dorsal neural fates. During neural development, BMPs are expressed in the roof plate and adjacent neuroepithelium. Because several hindbrain nuclei that form the proprioceptive/vestibular/auditory sensory network originate...
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226602&type=printable |
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| author | Lihua Qin Kyung J Ahn Lara Wine Lee Charles de Charleroy E Bryan Crenshaw |
| author_facet | Lihua Qin Kyung J Ahn Lara Wine Lee Charles de Charleroy E Bryan Crenshaw |
| author_sort | Lihua Qin |
| collection | DOAJ |
| description | Bone morphogenetic proteins (BMPs) have been hypothesized to specify distinct dorsal neural fates. During neural development, BMPs are expressed in the roof plate and adjacent neuroepithelium. Because several hindbrain nuclei that form the proprioceptive/vestibular/auditory sensory network originate from the rhombic lip, near the roof plate, BMP signaling may regulate the development of these nuclei. To test this hypothesis genetically, we have examined the development of the hindbrain in BMP type I receptor knockout mice. Our results demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei, which give rise to cerebellar mossy fibers, but is not required for the development of the inferior olivary nucleus, which gives rise to cerebellar climbing fibers. |
| format | Article |
| id | doaj-art-e49e460062344a5284df5d216bb40c19 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e49e460062344a5284df5d216bb40c192025-08-20T02:55:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-011412e022660210.1371/journal.pone.0226602Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip.Lihua QinKyung J AhnLara Wine LeeCharles de CharleroyE Bryan CrenshawBone morphogenetic proteins (BMPs) have been hypothesized to specify distinct dorsal neural fates. During neural development, BMPs are expressed in the roof plate and adjacent neuroepithelium. Because several hindbrain nuclei that form the proprioceptive/vestibular/auditory sensory network originate from the rhombic lip, near the roof plate, BMP signaling may regulate the development of these nuclei. To test this hypothesis genetically, we have examined the development of the hindbrain in BMP type I receptor knockout mice. Our results demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei, which give rise to cerebellar mossy fibers, but is not required for the development of the inferior olivary nucleus, which gives rise to cerebellar climbing fibers.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226602&type=printable |
| spellingShingle | Lihua Qin Kyung J Ahn Lara Wine Lee Charles de Charleroy E Bryan Crenshaw Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip. PLoS ONE |
| title | Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip. |
| title_full | Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip. |
| title_fullStr | Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip. |
| title_full_unstemmed | Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip. |
| title_short | Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip. |
| title_sort | analyses with double knockouts of the bmpr1a and bmpr1b genes demonstrate that bmp signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226602&type=printable |
| work_keys_str_mv | AT lihuaqin analyseswithdoubleknockoutsofthebmpr1aandbmpr1bgenesdemonstratethatbmpsignalingisinvolvedintheformationofprecerebellarmossyfibernucleiderivedfromtherhombiclip AT kyungjahn analyseswithdoubleknockoutsofthebmpr1aandbmpr1bgenesdemonstratethatbmpsignalingisinvolvedintheformationofprecerebellarmossyfibernucleiderivedfromtherhombiclip AT larawinelee analyseswithdoubleknockoutsofthebmpr1aandbmpr1bgenesdemonstratethatbmpsignalingisinvolvedintheformationofprecerebellarmossyfibernucleiderivedfromtherhombiclip AT charlesdecharleroy analyseswithdoubleknockoutsofthebmpr1aandbmpr1bgenesdemonstratethatbmpsignalingisinvolvedintheformationofprecerebellarmossyfibernucleiderivedfromtherhombiclip AT ebryancrenshaw analyseswithdoubleknockoutsofthebmpr1aandbmpr1bgenesdemonstratethatbmpsignalingisinvolvedintheformationofprecerebellarmossyfibernucleiderivedfromtherhombiclip |