Molecular dynamics reveal potential effects of novel VHL variants on VHL-Elongin C binding in ccRCC patients from Eastern India

Molecular dynamics reveal potential effects of novel VHL variants on VHL-Elongin C binding in ccRCC patients from Eastern India

Abstract Renal cell carcinoma (RCC) is the one of the most fatal and frequent form of urological malignancy worldwide. The von Hippel-Lindau (VHL) tumour suppressor gene is a critical component of the VHL-Cullin2-ElonginB/C (VCB) complex that regulates the ubiquitin-mediated proteasomal degradation...

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Main Authors: Srilagna Chatterjee, Nirvika Paul, Anwesha Das, Sarbashri Bank, Biswabandhu Bankura, Ravi Prakash Yadav, Kunal Sarkar, Soumen Saha, Subhajit Malakar, Sunirmal Choudhury, Sudakshina Ghosh, Madhusudan Das
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
VHL
Renal cell carcinoma (RCC)
Novel mutations
In silico
Protein flexibility modelling
Online Access:https://doi.org/10.1038/s41598-025-95875-1
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