New insights into DEHP-induced inflammatory injury in chicken spleen: ROS/TLR4/MyD88 pathway and apoptosis/necroptosis-M1 polarization crosstalk

New insights into DEHP-induced inflammatory injury in chicken spleen: ROS/TLR4/MyD88 pathway and apoptosis/necroptosis-M1 polarization crosstalk

The environmental endocrine disruptor di(2-ethylhexyl) phthalate (DEHP) is a plasticiser used in large quantities in plastics and is hazardous to the health of humans and various animals. DEHP can be immunotoxic to the spleen through oxidative stress. Still, the role of splenic macrophage polarizati...

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Bibliographic Details
Main Authors: Yue Xu, Xiandan Zhang, Guangxing Li, Rong Guo, Hong Zhang, Bolin Zhao, Xiaoyu Zhao, Kaiting Chen, Xiaodan Huang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Poultry Science
Subjects:
Di-(2-ethylhexyl) phthalate
Spleen inflammation
ROS/TLR4/MyD88 pathway
Apoptosis/necroptosis-M1 polarization crosstalk
Chicken
Online Access:http://www.sciencedirect.com/science/article/pii/S003257912500313X
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