Construction and validation of a risk model of proteinuria in patients with omicron COVID‐19: retrospective cohort study
Background To explore the risk factors of proteinuria in Omicron variant patients and to construct and verify the risk predictive model.Methods 1091 Omicron patients who were hospitalized from August 2022 to November 2022 at Tianjin First Central Hospital were defined as the derivation cohort. 306 O...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2365979 |
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| author | Lanbo Teng Ge Chang Xinyuan Song Miaomiao Zhang Yingying Han Wenxiu Chang Zhongyang Shen |
| author_facet | Lanbo Teng Ge Chang Xinyuan Song Miaomiao Zhang Yingying Han Wenxiu Chang Zhongyang Shen |
| author_sort | Lanbo Teng |
| collection | DOAJ |
| description | Background To explore the risk factors of proteinuria in Omicron variant patients and to construct and verify the risk predictive model.Methods 1091 Omicron patients who were hospitalized from August 2022 to November 2022 at Tianjin First Central Hospital were defined as the derivation cohort. 306 Omicron patients who were hospitalized from January 2022 to March 2022 at the same hospital were defined as the validation cohort. The risk factors of proteinuria in derivation cohort were screened by univariate and multivariate logistic regression analysis, and proteinuria predicting scoring system was constructed and the receiver operating characteristic(ROC)curve was drawn to test the prediction ability. The proteinuria risk model was externally validated in validation cohort.Results 7 factors including comorbidities, blood urea nitrogen (BUN), serum sodium (Na), uric acid (UA), C reactive protein (CRP) and vaccine dosages were included to construct a risk predictive model. The score ranged from −5 to 16. The area under the ROC curve(AUC) of the model was 0.8326(95% CI 0.7816 to 0.8835, p < 0.0001). Similarly to that observed in derivation cohort, the AUC is 0.833(95% CI 0.7808 to 0.9002, p < 0.0001), which verified good prediction ability and diagnostic accuracy in validation cohort.Conclusions The risk model of proteinuria after Omicron infection had better assessing efficiency which could provide reference for clinical prediction of the risk of proteinuria in Omicron patients. |
| format | Article |
| id | doaj-art-e49a5925ebbb42648ad9147a3f550464 |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-e49a5925ebbb42648ad9147a3f5504642025-08-20T03:21:30ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2365979Construction and validation of a risk model of proteinuria in patients with omicron COVID‐19: retrospective cohort studyLanbo Teng0Ge Chang1Xinyuan Song2Miaomiao Zhang3Yingying Han4Wenxiu Chang5Zhongyang Shen6Department of Nephrology, Tianjin First Central Hospital, Nankai University, Tianjin, ChinaDepartment of Clinical Medicine, Tianjin Medical University, Tianjin, ChinaDepartment of Nephrology, Tianjin First Central Hospital, Nankai University, Tianjin, ChinaDepartment of Nephrology, Tianjin First Central Hospital, Nankai University, Tianjin, ChinaDepartment of Nephrology, Tianjin First Central Hospital, Nankai University, Tianjin, ChinaDepartment of Nephrology, Tianjin First Central Hospital, Nankai University, Tianjin, ChinaNational Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, ChinaBackground To explore the risk factors of proteinuria in Omicron variant patients and to construct and verify the risk predictive model.Methods 1091 Omicron patients who were hospitalized from August 2022 to November 2022 at Tianjin First Central Hospital were defined as the derivation cohort. 306 Omicron patients who were hospitalized from January 2022 to March 2022 at the same hospital were defined as the validation cohort. The risk factors of proteinuria in derivation cohort were screened by univariate and multivariate logistic regression analysis, and proteinuria predicting scoring system was constructed and the receiver operating characteristic(ROC)curve was drawn to test the prediction ability. The proteinuria risk model was externally validated in validation cohort.Results 7 factors including comorbidities, blood urea nitrogen (BUN), serum sodium (Na), uric acid (UA), C reactive protein (CRP) and vaccine dosages were included to construct a risk predictive model. The score ranged from −5 to 16. The area under the ROC curve(AUC) of the model was 0.8326(95% CI 0.7816 to 0.8835, p < 0.0001). Similarly to that observed in derivation cohort, the AUC is 0.833(95% CI 0.7808 to 0.9002, p < 0.0001), which verified good prediction ability and diagnostic accuracy in validation cohort.Conclusions The risk model of proteinuria after Omicron infection had better assessing efficiency which could provide reference for clinical prediction of the risk of proteinuria in Omicron patients.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2365979Proteinuriaomicronrisk factorsrisk model |
| spellingShingle | Lanbo Teng Ge Chang Xinyuan Song Miaomiao Zhang Yingying Han Wenxiu Chang Zhongyang Shen Construction and validation of a risk model of proteinuria in patients with omicron COVID‐19: retrospective cohort study Renal Failure Proteinuria omicron risk factors risk model |
| title | Construction and validation of a risk model of proteinuria in patients with omicron COVID‐19: retrospective cohort study |
| title_full | Construction and validation of a risk model of proteinuria in patients with omicron COVID‐19: retrospective cohort study |
| title_fullStr | Construction and validation of a risk model of proteinuria in patients with omicron COVID‐19: retrospective cohort study |
| title_full_unstemmed | Construction and validation of a risk model of proteinuria in patients with omicron COVID‐19: retrospective cohort study |
| title_short | Construction and validation of a risk model of proteinuria in patients with omicron COVID‐19: retrospective cohort study |
| title_sort | construction and validation of a risk model of proteinuria in patients with omicron covid 19 retrospective cohort study |
| topic | Proteinuria omicron risk factors risk model |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2365979 |
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