Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer

Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer

Abstract Background Despite extensive analysis, the dynamic changes in prostate epithelial cell states during tissue homeostasis as well as tumor initiation and progression have been poorly characterized. However, recent advances in single-cell RNA-sequencing (scRNA-seq) technology have greatly faci...

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Bibliographic Details
Main Authors: Luis Aparicio, Laura Crowley, John R. Christin, Caroline J. Laplaca, Hanina Hibshoosh, Raul Rabadan, Michael M. Shen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Genome Medicine
Subjects:
Prostate cancer
ScRNA-seq
Tumor heterogeneity
Plasticity
Castration
Androgen receptor
Online Access:https://doi.org/10.1186/s13073-025-01432-w
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