Familial combined hyperlipidemia: current status of the problem (literature review)
Among the various dyslipidemia types, familial combined hyperlipidemia (FCH) is the most common genetic disorder, which is characterized by at least two different forms of lipid disorders: hypercholesterolemia and hypertriglyceridemia. In FCH, the risk of atherosclerotic cardiovascular diseases (CV...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2024-10-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5874 |
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| author | O. V. Timoshchenko E. V. Shakhtshneider |
| author_facet | O. V. Timoshchenko E. V. Shakhtshneider |
| author_sort | O. V. Timoshchenko |
| collection | DOAJ |
| description | Among the various dyslipidemia types, familial combined hyperlipidemia (FCH) is the most common genetic disorder, which is characterized by at least two different forms of lipid disorders: hypercholesterolemia and hypertriglyceridemia. In FCH, the risk of atherosclerotic cardiovascular diseases (CVDs), including at a young age, increases significantly. The aim was to analyze literature data on modern criteria for diagnosis, pathogenesis and data from molecular genetic studies of FCH. Future studies aimed at understanding the underlying genetic and metabolic mechanisms of FCH and developing effective treatment strategies should include larger cohort studies with greater genetic diversity, as well as investigation of epigenetic and lifestyle factors. |
| format | Article |
| id | doaj-art-e4963dfdb74847bdbd6e9dadcef650c6 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2024-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-e4963dfdb74847bdbd6e9dadcef650c62025-08-20T03:21:19Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202024-10-0129810.15829/1560-4071-2024-58744107Familial combined hyperlipidemia: current status of the problem (literature review)O. V. Timoshchenko0E. V. Shakhtshneider1Research Institute of Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute of Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and Genetics; Federal Research Center Institute of Cytology and GeneticsAmong the various dyslipidemia types, familial combined hyperlipidemia (FCH) is the most common genetic disorder, which is characterized by at least two different forms of lipid disorders: hypercholesterolemia and hypertriglyceridemia. In FCH, the risk of atherosclerotic cardiovascular diseases (CVDs), including at a young age, increases significantly. The aim was to analyze literature data on modern criteria for diagnosis, pathogenesis and data from molecular genetic studies of FCH. Future studies aimed at understanding the underlying genetic and metabolic mechanisms of FCH and developing effective treatment strategies should include larger cohort studies with greater genetic diversity, as well as investigation of epigenetic and lifestyle factors.https://russjcardiol.elpub.ru/jour/article/view/5874familial combined hyperlipidemiadyslipidemiamolecular genetic researchcardiovascular diseases |
| spellingShingle | O. V. Timoshchenko E. V. Shakhtshneider Familial combined hyperlipidemia: current status of the problem (literature review) Российский кардиологический журнал familial combined hyperlipidemia dyslipidemia molecular genetic research cardiovascular diseases |
| title | Familial combined hyperlipidemia: current status of the problem (literature review) |
| title_full | Familial combined hyperlipidemia: current status of the problem (literature review) |
| title_fullStr | Familial combined hyperlipidemia: current status of the problem (literature review) |
| title_full_unstemmed | Familial combined hyperlipidemia: current status of the problem (literature review) |
| title_short | Familial combined hyperlipidemia: current status of the problem (literature review) |
| title_sort | familial combined hyperlipidemia current status of the problem literature review |
| topic | familial combined hyperlipidemia dyslipidemia molecular genetic research cardiovascular diseases |
| url | https://russjcardiol.elpub.ru/jour/article/view/5874 |
| work_keys_str_mv | AT ovtimoshchenko familialcombinedhyperlipidemiacurrentstatusoftheproblemliteraturereview AT evshakhtshneider familialcombinedhyperlipidemiacurrentstatusoftheproblemliteraturereview |