Medication burden in patients with dialysis-dependent CKD: a systematic review
This systematic review aimed to statistically profile the medication burden and associated influencing factors, and outcomes in patients with dialysis-dependent chronic kidney disease (DD-CKD). Studies of medication burden in patients with DD-CKD in the last 10 years from 1 January 2013 to 31 March...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2353341 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591134016143360 |
|---|---|
| author | Xuemei Liu Ping Chen Yun Liu Xiaoyan Jia Dongmei Xu |
| author_facet | Xuemei Liu Ping Chen Yun Liu Xiaoyan Jia Dongmei Xu |
| author_sort | Xuemei Liu |
| collection | DOAJ |
| description | This systematic review aimed to statistically profile the medication burden and associated influencing factors, and outcomes in patients with dialysis-dependent chronic kidney disease (DD-CKD). Studies of medication burden in patients with DD-CKD in the last 10 years from 1 January 2013 to 31 March 2024 were searched from PubMed, Embase, and Cochrane databases. Newcastle-Ottawa Scale (NOS) or Agency for Healthcare Research and Quality (AHRQ) methodology checklist was used to evaluate quality and bias. Data extraction and combining from multiple groups of number (n), mean, and standard deviation (SD) were performed using R programming language (version4.3.1; R Core Team, Vienna, Austria). A total of 10 studies were included, and the results showed a higher drug burden in patients with DD-CKD. The combined pill burden was 14.57 ± 7.56 per day in hemodialysis (HD) patients and 14.63 ± 6.32 in peritoneal dialysis (PD) patients. The combined number of medications was 9.74 ± 3.37 in HD and 8 ± 3 in PD. Four studies described the various drug classes and their proportions, in general, antihypertensives and phosphate binders were the most commonly used drugs. Five studies mentioned factors associated with medication burden. A total of five studies mentioned medication burden-related outcomes, with one study finding that medication-related burden was associated with increased treatment burden, three studies finding that poor medication adherence was associated with medication burden, and another study finding that medication complexity was not associated with self-reported medication adherence. Limitations: meta-analysis was not possible due to the heterogeneity of studies. |
| format | Article |
| id | doaj-art-e495be0883af4a6b8add3562939e1021 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-e495be0883af4a6b8add3562939e10212025-01-23T04:17:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2353341Medication burden in patients with dialysis-dependent CKD: a systematic reviewXuemei Liu0Ping Chen1Yun Liu2Xiaoyan Jia3Dongmei Xu4Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaKey Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaThis systematic review aimed to statistically profile the medication burden and associated influencing factors, and outcomes in patients with dialysis-dependent chronic kidney disease (DD-CKD). Studies of medication burden in patients with DD-CKD in the last 10 years from 1 January 2013 to 31 March 2024 were searched from PubMed, Embase, and Cochrane databases. Newcastle-Ottawa Scale (NOS) or Agency for Healthcare Research and Quality (AHRQ) methodology checklist was used to evaluate quality and bias. Data extraction and combining from multiple groups of number (n), mean, and standard deviation (SD) were performed using R programming language (version4.3.1; R Core Team, Vienna, Austria). A total of 10 studies were included, and the results showed a higher drug burden in patients with DD-CKD. The combined pill burden was 14.57 ± 7.56 per day in hemodialysis (HD) patients and 14.63 ± 6.32 in peritoneal dialysis (PD) patients. The combined number of medications was 9.74 ± 3.37 in HD and 8 ± 3 in PD. Four studies described the various drug classes and their proportions, in general, antihypertensives and phosphate binders were the most commonly used drugs. Five studies mentioned factors associated with medication burden. A total of five studies mentioned medication burden-related outcomes, with one study finding that medication-related burden was associated with increased treatment burden, three studies finding that poor medication adherence was associated with medication burden, and another study finding that medication complexity was not associated with self-reported medication adherence. Limitations: meta-analysis was not possible due to the heterogeneity of studies.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2353341Dialysis-dependent chronic kidney diseasemedication burdenmedication regimen complexity indexsystematic reviewinterventions |
| spellingShingle | Xuemei Liu Ping Chen Yun Liu Xiaoyan Jia Dongmei Xu Medication burden in patients with dialysis-dependent CKD: a systematic review Renal Failure Dialysis-dependent chronic kidney disease medication burden medication regimen complexity index systematic review interventions |
| title | Medication burden in patients with dialysis-dependent CKD: a systematic review |
| title_full | Medication burden in patients with dialysis-dependent CKD: a systematic review |
| title_fullStr | Medication burden in patients with dialysis-dependent CKD: a systematic review |
| title_full_unstemmed | Medication burden in patients with dialysis-dependent CKD: a systematic review |
| title_short | Medication burden in patients with dialysis-dependent CKD: a systematic review |
| title_sort | medication burden in patients with dialysis dependent ckd a systematic review |
| topic | Dialysis-dependent chronic kidney disease medication burden medication regimen complexity index systematic review interventions |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2353341 |
| work_keys_str_mv | AT xuemeiliu medicationburdeninpatientswithdialysisdependentckdasystematicreview AT pingchen medicationburdeninpatientswithdialysisdependentckdasystematicreview AT yunliu medicationburdeninpatientswithdialysisdependentckdasystematicreview AT xiaoyanjia medicationburdeninpatientswithdialysisdependentckdasystematicreview AT dongmeixu medicationburdeninpatientswithdialysisdependentckdasystematicreview |