7-<i>O</i>-Carboxylic Acid-Substituted 3-<i>O</i>-Alkyl Difluoroquercetin; An Aztreonam-Potentiating Agent Against Carbapenemase-Producing <i>Pseudomonas aeruginosa</i> Through Simultaneous Inhibition of Metallo-β-Lactamase and Efflux Pump

7-<i>O</i>-Carboxylic Acid-Substituted 3-<i>O</i>-Alkyl Difluoroquercetin; An Aztreonam-Potentiating Agent Against Carbapenemase-Producing <i>Pseudomonas aeruginosa</i> Through Simultaneous Inhibition of Metallo-β-Lactamase and Efflux Pump

<b>Background/Objectives:</b> Previously, we reported that 3-<i>O</i>-alkyl difluoroquercetins (di-F-Q) potentiates the antimicrobial activity of aztreonam (ATM) against metallo-β-lactamase (MBL)-producing <i>P. aeruginosa</i> through simultaneous inhibition of MB...

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Bibliographic Details
Main Authors: Seongyeon Lee, Taegum Lee, Mi Kyoung Kim, Joong Hoon Ahn, Seri Jeong, Ki-Ho Park, Youhoon Chong
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antibiotics
Subjects:
<i>Pseudomonas aeruginosa</i>
metallo-β-lactamase
efflux pump
simultaneous inhibition
aztreonam
potentiation
Online Access:https://www.mdpi.com/2079-6382/13/12/1202
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