Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-Needling
Regenerative dentistry has seen significant advancements with the integration of innovative biotechnological approaches aimed at enhancing tissue repair and regeneration. Injectable platelet-rich fibrin (i-PRF) and micro-needling are two emerging techniques with synergistic potential for promoting t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_290_25 |
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| author | Priyanka Vhanmane Vidya Dodwad Jeeth P. Rai Sandipan Sarkar Pranav Bharat Heshi Mrunmayee Atkare |
| author_facet | Priyanka Vhanmane Vidya Dodwad Jeeth P. Rai Sandipan Sarkar Pranav Bharat Heshi Mrunmayee Atkare |
| author_sort | Priyanka Vhanmane |
| collection | DOAJ |
| description | Regenerative dentistry has seen significant advancements with the integration of innovative biotechnological approaches aimed at enhancing tissue repair and regeneration. Injectable platelet-rich fibrin (i-PRF) and micro-needling are two emerging techniques with synergistic potential for promoting tissue healing and regeneration. i-PRF, a second-generation platelet concentrate, is rich in growth factors and cytokines that facilitate cellular proliferation, angiogenesis, and extracellular matrix remodeling. Micro-needling, on the other hand, induces controlled micro-injuries to the tissue, triggering a cascade of biological responses that amplify natural healing processes. This review explores the individual and combined effects of i-PRF and micro-needling in regenerative dentistry, focusing on their mechanisms of action, clinical applications, and the underlying molecular pathways that drive their synergistic potential. The integration of these techniques offers promising outcomes in soft tissue healing, periodontal regeneration, and bone remodeling, enhancing gingival phenotype, and providing a minimally invasive, patient-centric approach. |
| format | Article |
| id | doaj-art-e48f417efc1047dcb75b9560df99d411 |
| institution | DOAJ |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-e48f417efc1047dcb75b9560df99d4112025-08-20T03:15:20ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1073S107510.4103/jpbs.jpbs_290_25Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-NeedlingPriyanka VhanmaneVidya DodwadJeeth P. RaiSandipan SarkarPranav Bharat HeshiMrunmayee AtkareRegenerative dentistry has seen significant advancements with the integration of innovative biotechnological approaches aimed at enhancing tissue repair and regeneration. Injectable platelet-rich fibrin (i-PRF) and micro-needling are two emerging techniques with synergistic potential for promoting tissue healing and regeneration. i-PRF, a second-generation platelet concentrate, is rich in growth factors and cytokines that facilitate cellular proliferation, angiogenesis, and extracellular matrix remodeling. Micro-needling, on the other hand, induces controlled micro-injuries to the tissue, triggering a cascade of biological responses that amplify natural healing processes. This review explores the individual and combined effects of i-PRF and micro-needling in regenerative dentistry, focusing on their mechanisms of action, clinical applications, and the underlying molecular pathways that drive their synergistic potential. The integration of these techniques offers promising outcomes in soft tissue healing, periodontal regeneration, and bone remodeling, enhancing gingival phenotype, and providing a minimally invasive, patient-centric approach.https://journals.lww.com/10.4103/jpbs.jpbs_290_25bone remodelinggrowth factorsinjectable platelet-rich fibrini-prfmicro-needlingminimally invasive techniquesperiodontal healingregenerative dentistrysynergistic effectstissue regeneration |
| spellingShingle | Priyanka Vhanmane Vidya Dodwad Jeeth P. Rai Sandipan Sarkar Pranav Bharat Heshi Mrunmayee Atkare Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-Needling Journal of Pharmacy and Bioallied Sciences bone remodeling growth factors injectable platelet-rich fibrin i-prf micro-needling minimally invasive techniques periodontal healing regenerative dentistry synergistic effects tissue regeneration |
| title | Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-Needling |
| title_full | Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-Needling |
| title_fullStr | Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-Needling |
| title_full_unstemmed | Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-Needling |
| title_short | Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-Needling |
| title_sort | innovative approaches in regenerative dentistry a review on the synergistic effects of injectable platelet rich fibrin i prf and micro needling |
| topic | bone remodeling growth factors injectable platelet-rich fibrin i-prf micro-needling minimally invasive techniques periodontal healing regenerative dentistry synergistic effects tissue regeneration |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_290_25 |
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