Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19
Background. Chronic low-grade inflammation associated with a dysregulated adipose tissue might contribute to amplifying the inflammatory response in severe COVID-19. The aim of this study was to examine the association between levels of circulating leptin and adiponectin and the severity and mortali...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2023/4427873 |
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| author | Bettina Hindsberger Birgitte Lindegaard Liv Rabøl Andersen Simone Bastrup Israelsen Lise Pedersen Pal Bela Szecsi Thomas Benfield |
| author_facet | Bettina Hindsberger Birgitte Lindegaard Liv Rabøl Andersen Simone Bastrup Israelsen Lise Pedersen Pal Bela Szecsi Thomas Benfield |
| author_sort | Bettina Hindsberger |
| collection | DOAJ |
| description | Background. Chronic low-grade inflammation associated with a dysregulated adipose tissue might contribute to amplifying the inflammatory response in severe COVID-19. The aim of this study was to examine the association between levels of circulating leptin and adiponectin and the severity and mortality of COVID-19. Methods. Serum levels of leptin and adiponectin were determined at admission in 123 individuals with confirmed COVID-19 and their association with 90-day mortality and respiratory failure was analyzed by logistic regression analysis and expressed as odds ratios (ORs) with 95% confidence intervals (CIs). Results. The median values of circulating leptin and adiponectin were 7.2 ng/mL (IQR 3.8–13.4) and 9.0 μg/mL (IQR 5.7–14.6), respectively. After adjustment for age, sex, body mass index, hypertension, diabetes, chronic obstructive pulmonary disease, and oxygen saturation at admission, a doubling of circulating adiponectin was associated with a 38% reduction in odds of 90-day mortality (OR 0.62, CI 0.43–0.89) and a 40% reduction in odds of respiratory failure (OR 0.60, CI 0.42–0.86). The association tended to be strongest in individuals below the median age of 72 years. Circulating leptin was not associated with outcomes. Conclusions. Circulating adiponectin at admission was inversely associated with mortality and respiratory failure in SARS-CoV-2 infection. Further studies are needed to elucidate how exactly adipokines, especially adiponectin, are linked to the progression and prognosis of COVID-19. |
| format | Article |
| id | doaj-art-e489f6ab12ed4857904e2c67eb93fa96 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e489f6ab12ed4857904e2c67eb93fa962025-08-20T03:26:26ZengWileyInternational Journal of Endocrinology1687-83452023-01-01202310.1155/2023/4427873Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19Bettina Hindsberger0Birgitte Lindegaard1Liv Rabøl Andersen2Simone Bastrup Israelsen3Lise Pedersen4Pal Bela Szecsi5Thomas Benfield6Center of Clinical Research and Disruption of Infectious Diseases (CREDID)Department of Infectious DiseasesCenter of Clinical Research and Disruption of Infectious Diseases (CREDID)Center of Clinical Research and Disruption of Infectious Diseases (CREDID)Department of Clinical BiochemistryDepartment of Clinical BiochemistryCenter of Clinical Research and Disruption of Infectious Diseases (CREDID)Background. Chronic low-grade inflammation associated with a dysregulated adipose tissue might contribute to amplifying the inflammatory response in severe COVID-19. The aim of this study was to examine the association between levels of circulating leptin and adiponectin and the severity and mortality of COVID-19. Methods. Serum levels of leptin and adiponectin were determined at admission in 123 individuals with confirmed COVID-19 and their association with 90-day mortality and respiratory failure was analyzed by logistic regression analysis and expressed as odds ratios (ORs) with 95% confidence intervals (CIs). Results. The median values of circulating leptin and adiponectin were 7.2 ng/mL (IQR 3.8–13.4) and 9.0 μg/mL (IQR 5.7–14.6), respectively. After adjustment for age, sex, body mass index, hypertension, diabetes, chronic obstructive pulmonary disease, and oxygen saturation at admission, a doubling of circulating adiponectin was associated with a 38% reduction in odds of 90-day mortality (OR 0.62, CI 0.43–0.89) and a 40% reduction in odds of respiratory failure (OR 0.60, CI 0.42–0.86). The association tended to be strongest in individuals below the median age of 72 years. Circulating leptin was not associated with outcomes. Conclusions. Circulating adiponectin at admission was inversely associated with mortality and respiratory failure in SARS-CoV-2 infection. Further studies are needed to elucidate how exactly adipokines, especially adiponectin, are linked to the progression and prognosis of COVID-19.http://dx.doi.org/10.1155/2023/4427873 |
| spellingShingle | Bettina Hindsberger Birgitte Lindegaard Liv Rabøl Andersen Simone Bastrup Israelsen Lise Pedersen Pal Bela Szecsi Thomas Benfield Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19 International Journal of Endocrinology |
| title | Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19 |
| title_full | Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19 |
| title_fullStr | Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19 |
| title_full_unstemmed | Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19 |
| title_short | Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19 |
| title_sort | circulating adiponectin levels are inversely associated with mortality and respiratory failure in patients hospitalized with covid 19 |
| url | http://dx.doi.org/10.1155/2023/4427873 |
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