Macrococcus caseolyticus in early-onset neonatal sepsis, Kassala, Sudan
Introduction: Neonatal sepsis, a clinical syndrome characterized by systemic signs of infection in newborn infants (< 28 days old), are a significant cause of neonatal mortality and long-term morbidity globally, particularly in low- and middle- income countries. Case presentation: We report th...
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The Journal of Infection in Developing Countries
2025-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/21090 |
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| author | Abdualmoneim O Musa Antonella Santona Mohamed AA Desogi Maura Fiamma Ali Adam Duaa H Ibrahim Faiza A Hajedriss Fatima A Almake Mahmoud T Faki Mohamed I Awadap Elisa Taviani Salvatore Rubino Bianca Paglietti |
| author_facet | Abdualmoneim O Musa Antonella Santona Mohamed AA Desogi Maura Fiamma Ali Adam Duaa H Ibrahim Faiza A Hajedriss Fatima A Almake Mahmoud T Faki Mohamed I Awadap Elisa Taviani Salvatore Rubino Bianca Paglietti |
| author_sort | Abdualmoneim O Musa |
| collection | DOAJ |
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Introduction: Neonatal sepsis, a clinical syndrome characterized by systemic signs of infection in newborn infants (< 28 days old), are a significant cause of neonatal mortality and long-term morbidity globally, particularly in low- and middle- income countries.
Case presentation: We report the first case of neonatal sepsis caused by Macrococcus caseolyticus in a 48-hours old newborn who attended to the intensive care unit (ICU) of the Kassala Specialized Hospital for Pediatrics in Sudan, with signs of severe bacterial infection. M. caseolyticus is an opportunistic pathogen normally associated with veterinary and food-borne infections. Empirical antibiotic therapy was promptly initiated following blood sampling and culture, resulting in recovery within 4 days. M. caseolyticus was identified by mass spectrometry and confirmed by whole genome sequencing. The isolated strain, KaM20, was resistant to tetracycline, due to the presence of the tet(L) gene; and harbored several virulence-associated genes. Phylogenetic analysis including M. caseolyticus genomes from the GenBank suggested an animal origin for KaM20.
Conclusions: This case presents a rare instance of neonatal sepsis caused by M. caseolyticus; indicating potential zoonotic transmission of this pathogen, through maternal or environmental exposure to animals in the rural household. The findings emphasize the need for increased awareness of zoonotic infections in neonatal care, particularly in regions where exposure to animals is common; and underscore the importance of understanding the complex interplay between host factors, environmental exposures, and microbial pathogens, in the development of neonatal sepsis; reinforcing the need of a 'One Health' approach in addressing emerging infectious diseases.
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| format | Article |
| id | doaj-art-e489f4fbef0748f0a65f3b250b6e439c |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-e489f4fbef0748f0a65f3b250b6e439c2025-08-20T03:52:43ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802025-03-01190310.3855/jidc.21090Macrococcus caseolyticus in early-onset neonatal sepsis, Kassala, SudanAbdualmoneim O Musa0Antonella Santona1Mohamed AA Desogi2Maura Fiamma3Ali Adam4Duaa H Ibrahim5Faiza A Hajedriss6Fatima A Almake7Mahmoud T Faki8Mohamed I Awadap9Elisa Taviani10Salvatore Rubino11Bianca Paglietti12Department of Microbiology, Faculty of Medical Laboratory Sciences, University of Kassala, Kassala, SudanDepartment of Biomedical Sciences, University of Sassari, Sassari, ItalyDepartment of Pediatrics, Faculty of Medicine and Health Sciences, University of Kassala, Kassala, SudanLaboratories Analisi, Ospedale "San Francesco", ASSL 08100 Nuoro, ItalyPublic Health Laboratory, Ministry of Health, Kassala State, Kassala, SudanDepartment of Microbiology, Faculty of Medical Laboratory Sciences, University of Kassala, Kassala, SudanDepartment of Microbiology, Faculty of Medical Laboratory Sciences, University of Kassala, Kassala, SudanDepartment of Microbiology, Faculty of Medical Laboratory Sciences, University of Kassala, Kassala, SudanPublic Health Laboratory, Ministry of Health, Kassala State, Kassala, SudanPublic Health Laboratory, Ministry of Health, Kassala State, Kassala, SudanEarth Department, Environmental and Life Sciences, DISTAV, University of Genoa, Genoa, ItalyDepartment of Biomedical Sciences, University of Sassari, Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy Introduction: Neonatal sepsis, a clinical syndrome characterized by systemic signs of infection in newborn infants (< 28 days old), are a significant cause of neonatal mortality and long-term morbidity globally, particularly in low- and middle- income countries. Case presentation: We report the first case of neonatal sepsis caused by Macrococcus caseolyticus in a 48-hours old newborn who attended to the intensive care unit (ICU) of the Kassala Specialized Hospital for Pediatrics in Sudan, with signs of severe bacterial infection. M. caseolyticus is an opportunistic pathogen normally associated with veterinary and food-borne infections. Empirical antibiotic therapy was promptly initiated following blood sampling and culture, resulting in recovery within 4 days. M. caseolyticus was identified by mass spectrometry and confirmed by whole genome sequencing. The isolated strain, KaM20, was resistant to tetracycline, due to the presence of the tet(L) gene; and harbored several virulence-associated genes. Phylogenetic analysis including M. caseolyticus genomes from the GenBank suggested an animal origin for KaM20. Conclusions: This case presents a rare instance of neonatal sepsis caused by M. caseolyticus; indicating potential zoonotic transmission of this pathogen, through maternal or environmental exposure to animals in the rural household. The findings emphasize the need for increased awareness of zoonotic infections in neonatal care, particularly in regions where exposure to animals is common; and underscore the importance of understanding the complex interplay between host factors, environmental exposures, and microbial pathogens, in the development of neonatal sepsis; reinforcing the need of a 'One Health' approach in addressing emerging infectious diseases. https://jidc.org/index.php/journal/article/view/21090neonatal sepsisMacrococcus caseolyticusKassala |
| spellingShingle | Abdualmoneim O Musa Antonella Santona Mohamed AA Desogi Maura Fiamma Ali Adam Duaa H Ibrahim Faiza A Hajedriss Fatima A Almake Mahmoud T Faki Mohamed I Awadap Elisa Taviani Salvatore Rubino Bianca Paglietti Macrococcus caseolyticus in early-onset neonatal sepsis, Kassala, Sudan Journal of Infection in Developing Countries neonatal sepsis Macrococcus caseolyticus Kassala |
| title | Macrococcus caseolyticus in early-onset neonatal sepsis, Kassala, Sudan |
| title_full | Macrococcus caseolyticus in early-onset neonatal sepsis, Kassala, Sudan |
| title_fullStr | Macrococcus caseolyticus in early-onset neonatal sepsis, Kassala, Sudan |
| title_full_unstemmed | Macrococcus caseolyticus in early-onset neonatal sepsis, Kassala, Sudan |
| title_short | Macrococcus caseolyticus in early-onset neonatal sepsis, Kassala, Sudan |
| title_sort | macrococcus caseolyticus in early onset neonatal sepsis kassala sudan |
| topic | neonatal sepsis Macrococcus caseolyticus Kassala |
| url | https://jidc.org/index.php/journal/article/view/21090 |
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