The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal Failure
Objective: to study the effectiveness of some types of semipermeable dialysis membranes and replacement therapy techniques in patients with isolated acute renal failure (iARF). Subjects and methods: Eighty-nine patients aged 24 to 67 years, who received intensive and replacement/maintenance therapy,...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2010-10-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/390 |
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| author | M. A. Yampolsky I. B. Zabolotskikh A. F. Yampolsky |
| author_facet | M. A. Yampolsky I. B. Zabolotskikh A. F. Yampolsky |
| author_sort | M. A. Yampolsky |
| collection | DOAJ |
| description | Objective: to study the effectiveness of some types of semipermeable dialysis membranes and replacement therapy techniques in patients with isolated acute renal failure (iARF). Subjects and methods: Eighty-nine patients aged 24 to 67 years, who received intensive and replacement/maintenance therapy, were examined. The patients were divided into 3 groups in accordance with their condition rated by the APACHE III scale, from the used dialysis membranes and renal replacement/maintenance therapy options. Results. By varying the permeability of a membrane, its area and the volume of convection, we can control the rate of substance elimination, which is similar to that of test markers having a molecular weight of 100 to 15000 Da. Conclusion. Adequate replacement therapy for iARF is possible only when high-flux, high-permeability dia-lyzers are applied. The indices of hemodialysis/hemodiafiltration adequacy in terms of urea cannot be determinants in patients with iARF. The achievement of elimination of low-molecular-weight proteins — markers of uremic intoxication to 30—35% and/or an increase in effective albumin concentrations as a summary marker of toxicity by 16—20% is of much more importance. Key words: isolated acute renal failure, uremic toxins, hemodialysis, hemodiafiltration. |
| format | Article |
| id | doaj-art-e489d576cff64e3494325b83e9abe7bc |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2010-10-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-e489d576cff64e3494325b83e9abe7bc2025-08-20T03:35:10ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102010-10-016510.15360/1813-9779-2010-5-40390The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal FailureM. A. YampolskyI. B. ZabolotskikhA. F. YampolskyObjective: to study the effectiveness of some types of semipermeable dialysis membranes and replacement therapy techniques in patients with isolated acute renal failure (iARF). Subjects and methods: Eighty-nine patients aged 24 to 67 years, who received intensive and replacement/maintenance therapy, were examined. The patients were divided into 3 groups in accordance with their condition rated by the APACHE III scale, from the used dialysis membranes and renal replacement/maintenance therapy options. Results. By varying the permeability of a membrane, its area and the volume of convection, we can control the rate of substance elimination, which is similar to that of test markers having a molecular weight of 100 to 15000 Da. Conclusion. Adequate replacement therapy for iARF is possible only when high-flux, high-permeability dia-lyzers are applied. The indices of hemodialysis/hemodiafiltration adequacy in terms of urea cannot be determinants in patients with iARF. The achievement of elimination of low-molecular-weight proteins — markers of uremic intoxication to 30—35% and/or an increase in effective albumin concentrations as a summary marker of toxicity by 16—20% is of much more importance. Key words: isolated acute renal failure, uremic toxins, hemodialysis, hemodiafiltration.https://www.reanimatology.com/rmt/article/view/390 |
| spellingShingle | M. A. Yampolsky I. B. Zabolotskikh A. F. Yampolsky The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal Failure Общая реаниматология |
| title | The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal Failure |
| title_full | The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal Failure |
| title_fullStr | The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal Failure |
| title_full_unstemmed | The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal Failure |
| title_short | The Elimination of Low-Molecular-Weight Proteins in Patients with Isolated Acute Renal Failure |
| title_sort | elimination of low molecular weight proteins in patients with isolated acute renal failure |
| url | https://www.reanimatology.com/rmt/article/view/390 |
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