Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management—A Narrative Review
<b>Background/Objectives:</b> Infertility in both men and women can be significantly influenced by oxidative stress (OS), which occurs due to an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses. In women, OS disrupts oocyte maturation, implantation, and...
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2025-06-01
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| author | Efthalia Moustakli Athanasios Zikopoulos Periklis Katopodis Stefanos Dafopoulos Vasilis Sebastian Paraschos Athanasios Zachariou Konstantinos Dafopoulos |
| author_facet | Efthalia Moustakli Athanasios Zikopoulos Periklis Katopodis Stefanos Dafopoulos Vasilis Sebastian Paraschos Athanasios Zachariou Konstantinos Dafopoulos |
| author_sort | Efthalia Moustakli |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Infertility in both men and women can be significantly influenced by oxidative stress (OS), which occurs due to an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses. In women, OS disrupts oocyte maturation, implantation, and the viability of the embryo; in men, it impairs sperm quality, reduces motility, and damages DNA integrity. This review explores existing research on how dietary and lifestyle interventions can reduce OS and enhance reproductive health outcomes. <b>Methods:</b> We conducted a comprehensive review of clinical, translational, and molecular studies exploring the mechanisms by which OS affects fertility, as well as the efficacy of nutritional and behavioral strategies. The interventions evaluated include weight management, regular exercise, micronutrient supplementation, antioxidant-rich diets, smoking and alcohol cessation, and stress-reduction techniques. <b>Results:</b> Specific dietary components such as zinc, selenium, vitamins C and E, and polyphenols have been found to neutralize reactive oxygen species (ROS) and enhance gamete function. OS is additionally reduced through lifestyle modifications, including minimizing harmful exposures, managing stress, and participating in moderate physical activity. Biomarkers such as ROS levels, total antioxidant capacity, 8-OHdG, and DNA fragmentation index are essential for assessing the effectiveness of interventions. <b>Conclusions:</b> Fertility in both sexes can be improved, and oxidative stress significantly reduced, through a multimodal approach incorporating dietary and lifestyle changes. There are encouraging opportunities to improve reproductive health through customized approaches that are informed by biomarker profiles. To incorporate these treatments into regular fertility care, future studies should concentrate on standardized procedures and long-term results. |
| format | Article |
| id | doaj-art-e48826b824c949b6b311b5dd437ead2b |
| institution | Kabale University |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-e48826b824c949b6b311b5dd437ead2b2025-08-20T03:27:15ZengMDPI AGMetabolites2218-19892025-06-0115637910.3390/metabo15060379Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management—A Narrative ReviewEfthalia Moustakli0Athanasios Zikopoulos1Periklis Katopodis2Stefanos Dafopoulos3Vasilis Sebastian Paraschos4Athanasios Zachariou5Konstantinos Dafopoulos6Laboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceLaboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Health Sciences, European University Cyprus, Nicosia 2404, CyprusCorewell Health Hospital, Department of Obstetrics and Gynecology, 4700 Schaefer Road Suite 310, Dearborn, MI 48126, USADepartment of Urology, School of Medicine, University of Ioannina, 45110 Ioannina, GreeceIVF Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece<b>Background/Objectives:</b> Infertility in both men and women can be significantly influenced by oxidative stress (OS), which occurs due to an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses. In women, OS disrupts oocyte maturation, implantation, and the viability of the embryo; in men, it impairs sperm quality, reduces motility, and damages DNA integrity. This review explores existing research on how dietary and lifestyle interventions can reduce OS and enhance reproductive health outcomes. <b>Methods:</b> We conducted a comprehensive review of clinical, translational, and molecular studies exploring the mechanisms by which OS affects fertility, as well as the efficacy of nutritional and behavioral strategies. The interventions evaluated include weight management, regular exercise, micronutrient supplementation, antioxidant-rich diets, smoking and alcohol cessation, and stress-reduction techniques. <b>Results:</b> Specific dietary components such as zinc, selenium, vitamins C and E, and polyphenols have been found to neutralize reactive oxygen species (ROS) and enhance gamete function. OS is additionally reduced through lifestyle modifications, including minimizing harmful exposures, managing stress, and participating in moderate physical activity. Biomarkers such as ROS levels, total antioxidant capacity, 8-OHdG, and DNA fragmentation index are essential for assessing the effectiveness of interventions. <b>Conclusions:</b> Fertility in both sexes can be improved, and oxidative stress significantly reduced, through a multimodal approach incorporating dietary and lifestyle changes. There are encouraging opportunities to improve reproductive health through customized approaches that are informed by biomarker profiles. To incorporate these treatments into regular fertility care, future studies should concentrate on standardized procedures and long-term results.https://www.mdpi.com/2218-1989/15/6/379oxidative stressfertilityantioxidantslifestyle interventionssperm qualityoocyte health |
| spellingShingle | Efthalia Moustakli Athanasios Zikopoulos Periklis Katopodis Stefanos Dafopoulos Vasilis Sebastian Paraschos Athanasios Zachariou Konstantinos Dafopoulos Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management—A Narrative Review Metabolites oxidative stress fertility antioxidants lifestyle interventions sperm quality oocyte health |
| title | Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management—A Narrative Review |
| title_full | Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management—A Narrative Review |
| title_fullStr | Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management—A Narrative Review |
| title_full_unstemmed | Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management—A Narrative Review |
| title_short | Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management—A Narrative Review |
| title_sort | dietary and lifestyle interventions to mitigate oxidative stress in male and female fertility practical insights for infertility management a narrative review |
| topic | oxidative stress fertility antioxidants lifestyle interventions sperm quality oocyte health |
| url | https://www.mdpi.com/2218-1989/15/6/379 |
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