Neurodegeneration: A Tale of Microbes and Neurons
The gut-brain axis has emerged as a central paradigm in understanding the bidirectional relationship between the gastrointestinal microbiota and the central nervous system (CNS), particularly within the context of neurodegenerative disorders. This review synthesizes contemporary insights into how mi...
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| Language: | English |
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Bucharest College of Physicians
2025-03-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2025/03/Neurodegeneration-A-Tale-of-Microbes-and-Neurons.pdf |
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| author | Octavian Costin IOGHEN Mihaela Roxana IOGHEN Bogdan Ovidiu POPESCU |
| author_facet | Octavian Costin IOGHEN Mihaela Roxana IOGHEN Bogdan Ovidiu POPESCU |
| author_sort | Octavian Costin IOGHEN |
| collection | DOAJ |
| description | The gut-brain axis has emerged as a central paradigm in understanding the bidirectional relationship between the gastrointestinal microbiota and the central nervous system (CNS), particularly within the context of neurodegenerative disorders. This review synthesizes contemporary insights into how microbial dysbiosis and vagal pathways orchestrate critical processes in neurodevelopment and neurodegeneration. We dissect the multifaceted mechanisms by which microbial constituents, including lipopolysaccharides, bacterial amyloids, and amphiphilic compounds, penetrate host barriers such as the blood-brain barrier, contributing to neuroinflammation, protein misfolding, and neuronal dysfunction—hallmarks of diseases like Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis. Although preclinical models present compelling findings, the need for longitudinal, large-scale clinical investigations remains critical. This synthesis underscores the gut microbiota as a therapeutic target within a precision medicine framework aimed at mitigating neurodegenerative disease onset and progression. |
| format | Article |
| id | doaj-art-e47f8188eb91474887ff35b2e148c7aa |
| institution | DOAJ |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-e47f8188eb91474887ff35b2e148c7aa2025-08-20T03:08:17ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732025-03-0132171610.31689/rmm.2025.32.1.7Neurodegeneration: A Tale of Microbes and NeuronsOctavian Costin IOGHEN0Mihaela Roxana IOGHEN1Bogdan Ovidiu POPESCU2https://orcid.org/0000-0003-4826-2598"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania"Carol Davila" University of Medicine and Pharmacy, Bucharest, RomaniaThe gut-brain axis has emerged as a central paradigm in understanding the bidirectional relationship between the gastrointestinal microbiota and the central nervous system (CNS), particularly within the context of neurodegenerative disorders. This review synthesizes contemporary insights into how microbial dysbiosis and vagal pathways orchestrate critical processes in neurodevelopment and neurodegeneration. We dissect the multifaceted mechanisms by which microbial constituents, including lipopolysaccharides, bacterial amyloids, and amphiphilic compounds, penetrate host barriers such as the blood-brain barrier, contributing to neuroinflammation, protein misfolding, and neuronal dysfunction—hallmarks of diseases like Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis. Although preclinical models present compelling findings, the need for longitudinal, large-scale clinical investigations remains critical. This synthesis underscores the gut microbiota as a therapeutic target within a precision medicine framework aimed at mitigating neurodegenerative disease onset and progression.https://medicinamoderna.ro/wp-content/uploads/2025/03/Neurodegeneration-A-Tale-of-Microbes-and-Neurons.pdfmicrobiotaneurodegenerationneuroinflammationparkinson’s disease |
| spellingShingle | Octavian Costin IOGHEN Mihaela Roxana IOGHEN Bogdan Ovidiu POPESCU Neurodegeneration: A Tale of Microbes and Neurons Modern Medicine microbiota neurodegeneration neuroinflammation parkinson’s disease |
| title | Neurodegeneration: A Tale of Microbes and Neurons |
| title_full | Neurodegeneration: A Tale of Microbes and Neurons |
| title_fullStr | Neurodegeneration: A Tale of Microbes and Neurons |
| title_full_unstemmed | Neurodegeneration: A Tale of Microbes and Neurons |
| title_short | Neurodegeneration: A Tale of Microbes and Neurons |
| title_sort | neurodegeneration a tale of microbes and neurons |
| topic | microbiota neurodegeneration neuroinflammation parkinson’s disease |
| url | https://medicinamoderna.ro/wp-content/uploads/2025/03/Neurodegeneration-A-Tale-of-Microbes-and-Neurons.pdf |
| work_keys_str_mv | AT octaviancostinioghen neurodegenerationataleofmicrobesandneurons AT mihaelaroxanaioghen neurodegenerationataleofmicrobesandneurons AT bogdanovidiupopescu neurodegenerationataleofmicrobesandneurons |