Research progress of potassium-competitive acid blockers in the treatment of Helicobacter pylori
Helicobacter pylori (H. pylori) infection is a primary pathogen responsible for gastrointestinal diseases, including gastritis, peptic ulcer disease, and gastric cancer. Therefore, the eradication of H. pylori is crucial for the prevention and treatment of these conditions. However, the increasing a...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2544886 |
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| author | Zhaoli Ma Shiling Wang Furui Wang Qian Ren |
| author_facet | Zhaoli Ma Shiling Wang Furui Wang Qian Ren |
| author_sort | Zhaoli Ma |
| collection | DOAJ |
| description | Helicobacter pylori (H. pylori) infection is a primary pathogen responsible for gastrointestinal diseases, including gastritis, peptic ulcer disease, and gastric cancer. Therefore, the eradication of H. pylori is crucial for the prevention and treatment of these conditions. However, the increasing antibiotic resistance has led to a gradual decline in the efficacy of traditional Proton Pump Inhibitors (PPIs) in triple or quadruple therapy, posing new challenges for H. pylori eradication. Potassium-competitive acid blockers (P-CAB) represent a novel class of acid-suppressing drugs that exert potent and sustained acid suppression by competitively inhibiting the potassium-binding site of the H+/K+-ATPase. Compared to traditional PPI, P-CAB offers advantages such as rapid onset of action, prolonged duration of effect, and less susceptibility to the influence of CYP2C19 genetic polymorphism, highlighting their significant potential in H. pylori eradication therapy. This article aims to comprehensively review the clinical efficacy and safety of P-CAB-containing regimens in first-line and rescue treatments for H. pylori eradication. This includes but is not limited to dual therapy combining P-CAB with other antibacterial agents, triple therapy, and quadruple therapy in combination with bismuth. By analyzing existing clinical research data, we will explore the application effects of P-CAB in different treatment regimens, as well as the advantages and potential limitations compared with PPI. Additionally, this article will focus on the tolerability of these treatment regimens in patients and the incidence of adverse reactions, to provide scientific evidence and new perspectives for clinicians in selecting appropriate H. pylori eradication regimens. |
| format | Article |
| id | doaj-art-e47e344facb34787a4cb06e24479f875 |
| institution | DOAJ |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-e47e344facb34787a4cb06e24479f8752025-08-20T03:03:51ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2544886Research progress of potassium-competitive acid blockers in the treatment of Helicobacter pyloriZhaoli Ma0Shiling Wang1Furui Wang2Qian Ren3The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu Province, ChinaGansu Health Vocational College, Lanzhou, Gansu Province, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu Province, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu Province, ChinaHelicobacter pylori (H. pylori) infection is a primary pathogen responsible for gastrointestinal diseases, including gastritis, peptic ulcer disease, and gastric cancer. Therefore, the eradication of H. pylori is crucial for the prevention and treatment of these conditions. However, the increasing antibiotic resistance has led to a gradual decline in the efficacy of traditional Proton Pump Inhibitors (PPIs) in triple or quadruple therapy, posing new challenges for H. pylori eradication. Potassium-competitive acid blockers (P-CAB) represent a novel class of acid-suppressing drugs that exert potent and sustained acid suppression by competitively inhibiting the potassium-binding site of the H+/K+-ATPase. Compared to traditional PPI, P-CAB offers advantages such as rapid onset of action, prolonged duration of effect, and less susceptibility to the influence of CYP2C19 genetic polymorphism, highlighting their significant potential in H. pylori eradication therapy. This article aims to comprehensively review the clinical efficacy and safety of P-CAB-containing regimens in first-line and rescue treatments for H. pylori eradication. This includes but is not limited to dual therapy combining P-CAB with other antibacterial agents, triple therapy, and quadruple therapy in combination with bismuth. By analyzing existing clinical research data, we will explore the application effects of P-CAB in different treatment regimens, as well as the advantages and potential limitations compared with PPI. Additionally, this article will focus on the tolerability of these treatment regimens in patients and the incidence of adverse reactions, to provide scientific evidence and new perspectives for clinicians in selecting appropriate H. pylori eradication regimens.https://www.tandfonline.com/doi/10.1080/07853890.2025.2544886Eradication therapygut microbiotaHelicobacter pyloripotassium-competitive acid blocker |
| spellingShingle | Zhaoli Ma Shiling Wang Furui Wang Qian Ren Research progress of potassium-competitive acid blockers in the treatment of Helicobacter pylori Annals of Medicine Eradication therapy gut microbiota Helicobacter pylori potassium-competitive acid blocker |
| title | Research progress of potassium-competitive acid blockers in the treatment of Helicobacter pylori |
| title_full | Research progress of potassium-competitive acid blockers in the treatment of Helicobacter pylori |
| title_fullStr | Research progress of potassium-competitive acid blockers in the treatment of Helicobacter pylori |
| title_full_unstemmed | Research progress of potassium-competitive acid blockers in the treatment of Helicobacter pylori |
| title_short | Research progress of potassium-competitive acid blockers in the treatment of Helicobacter pylori |
| title_sort | research progress of potassium competitive acid blockers in the treatment of helicobacter pylori |
| topic | Eradication therapy gut microbiota Helicobacter pylori potassium-competitive acid blocker |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2544886 |
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