Effects of Conformal Radiotherapy on Thyroid and Parathyroid Functions in Head-and-neck Carcinoma: A Single-institutional, Prospective, and Observational Study
Introduction: Assessment of acute and late effects of conformal radiotherapy on thyroid and parathyroid functions along with the evaluation of Dosimetric correlation with radiation-induced hypothyroidism (RIH) was the purpose of this study. Subjects and Methods: In this study, thyroid and parathyroi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Radiation and Cancer Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jrcr.jrcr_26_24 |
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| Summary: | Introduction:
Assessment of acute and late effects of conformal radiotherapy on thyroid and parathyroid functions along with the evaluation of Dosimetric correlation with radiation-induced hypothyroidism (RIH) was the purpose of this study.
Subjects and Methods:
In this study, thyroid and parathyroid functions were obtained from 40 patients of head-and neck carcinoma who had received conformal radiotherapy, at baseline, 6 weeks and 6 months after radiotherapy. The mean radiation dose (Dmean), volume, V20, V30 and V50 of thyroid gland were analyzed for Dosimetric correlation with RIH.
Statistical Analysis:
IBM SPSS software version 23 was used for the statistical analysis. Descriptive statistics, independent sample t-test, and pair sample t-test were performed.
Results:
The median follow-up period was 29 months. During the follow-up, 40% of total patients had developed RIH, among whom 37.5% of patients had laryngeal carcinoma as primary site. Dmean and volume of thyroid gland were found to be the strong predictors for RIH with P < 0.01. Fall in parathyroid hormone level after 6 weeks and 6 months of radiotherapy was also significant.
Conclusion:
Conformal radiotherapy has substantial effect on thyroid and parathyroid functions. Dmean and volume of thyroid gland can be considered as useful risk assessment tools for RIH. |
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| ISSN: | 2588-9273 2468-9203 |