Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia
Abstract Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections. We conducted a prospective local study of 335 K. pneumoniae isolates i...
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| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-025-00127-x |
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| author | Victor A. Medina Angela S. García-Vega Fernando Rodríguez Enmanuel S. Triviño-García Jaime A. Robledo Aura L. Leal Julián C. Galvis Luis F. Reyes Genomic Epidemiology of Antimicrobial Resistance Consortium (GEAR) Iruka N. Okeke Natacha Couto Emmanuelle A. Kumaran Georgina Lewis-Woodhouse Silvia Argimon Stefany A. Arevalo Anthony P. Underwood Xavier Fargetton David M. Aanensen Maria P. Donado-Godoy |
| author_facet | Victor A. Medina Angela S. García-Vega Fernando Rodríguez Enmanuel S. Triviño-García Jaime A. Robledo Aura L. Leal Julián C. Galvis Luis F. Reyes Genomic Epidemiology of Antimicrobial Resistance Consortium (GEAR) Iruka N. Okeke Natacha Couto Emmanuelle A. Kumaran Georgina Lewis-Woodhouse Silvia Argimon Stefany A. Arevalo Anthony P. Underwood Xavier Fargetton David M. Aanensen Maria P. Donado-Godoy |
| author_sort | Victor A. Medina |
| collection | DOAJ |
| description | Abstract Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections. We conducted a prospective local study of 335 K. pneumoniae isolates in 26 nationwide hospitals from 2020 to 2021. We found that the spread of carbapenem resistance was mediated by successful clones belonging to sequence types (ST) such as ST11, ST1082, and ST307, related to intra-hospital infections. We observed that bla KPC remains the primary resistance mechanism to carbapenems and that, unlike other countries, ST11 strains commonly carry bla KPC-3. We identified the recent introduction and circulation of new sequence types with different resistance mechanisms and hypervirulence. Besides, we detected possible transmission events closely linked to carbapenemase-carrying strains, mainly in intensive care units. This study helps us understand how K. pneumoniae disseminates in Colombian hospitals and where to direct effective intervention measures. |
| format | Article |
| id | doaj-art-e47d998e22064afb94499bfa2aab65b3 |
| institution | DOAJ |
| issn | 2731-8745 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-e47d998e22064afb94499bfa2aab65b32025-08-20T03:06:09ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-07-013111110.1038/s44259-025-00127-xEpidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across ColombiaVictor A. Medina0Angela S. García-Vega1Fernando Rodríguez2Enmanuel S. Triviño-García3Jaime A. Robledo4Aura L. Leal5Julián C. Galvis6Luis F. Reyes7Genomic Epidemiology of Antimicrobial Resistance Consortium (GEAR)Iruka N. Okeke8Natacha Couto9Emmanuelle A. Kumaran10Georgina Lewis-Woodhouse11Silvia Argimon12Stefany A. Arevalo13Anthony P. Underwood14Xavier Fargetton15David M. Aanensen16Maria P. Donado-Godoy17Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance (GHRU)-Colombia, CI Tibaitatá, Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA)Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance (GHRU)-Colombia, CI Tibaitatá, Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA)Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance (GHRU)-Colombia, CI Tibaitatá, Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA)Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance (GHRU)-Colombia, CI Tibaitatá, Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA)Grupo GERMEN – Laboratorio Médico de ReferenciaGrupo Para el Control de la Resistencia Bacteriana de Bogotá (GREBO), Facultad de Medicina, Universidad Nacional de ColombiaGrupo GERMEN – Laboratorio Médico de ReferenciaUnisabana Center for Translational Science, School of Medicine, Universidad de la SabanaCollege of Medicine, University of IbadanCentre for Genomic Pathogen Surveillance, Pandemics Science Institute, University of OxfordCentre for Genomic Pathogen Surveillance, Pandemics Science Institute, University of OxfordCentre for Genomic Pathogen Surveillance, Pandemics Science Institute, University of OxfordCentre for Genomic Pathogen Surveillance, Pandemics Science Institute, University of OxfordGlobal Health Research Unit on Genomic Surveillance of Antimicrobial Resistance (GHRU)-Colombia, CI Tibaitatá, Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA)Centre for Genomic Pathogen Surveillance, Pandemics Science Institute, University of OxfordGlobal Health Research Unit on Genomic Surveillance of Antimicrobial Resistance (GHRU)-Colombia, CI Tibaitatá, Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA)Centre for Genomic Pathogen Surveillance, Pandemics Science Institute, University of OxfordGlobal Health Research Unit on Genomic Surveillance of Antimicrobial Resistance (GHRU)-Colombia, CI Tibaitatá, Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA)Abstract Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections. We conducted a prospective local study of 335 K. pneumoniae isolates in 26 nationwide hospitals from 2020 to 2021. We found that the spread of carbapenem resistance was mediated by successful clones belonging to sequence types (ST) such as ST11, ST1082, and ST307, related to intra-hospital infections. We observed that bla KPC remains the primary resistance mechanism to carbapenems and that, unlike other countries, ST11 strains commonly carry bla KPC-3. We identified the recent introduction and circulation of new sequence types with different resistance mechanisms and hypervirulence. Besides, we detected possible transmission events closely linked to carbapenemase-carrying strains, mainly in intensive care units. This study helps us understand how K. pneumoniae disseminates in Colombian hospitals and where to direct effective intervention measures.https://doi.org/10.1038/s44259-025-00127-x |
| spellingShingle | Victor A. Medina Angela S. García-Vega Fernando Rodríguez Enmanuel S. Triviño-García Jaime A. Robledo Aura L. Leal Julián C. Galvis Luis F. Reyes Genomic Epidemiology of Antimicrobial Resistance Consortium (GEAR) Iruka N. Okeke Natacha Couto Emmanuelle A. Kumaran Georgina Lewis-Woodhouse Silvia Argimon Stefany A. Arevalo Anthony P. Underwood Xavier Fargetton David M. Aanensen Maria P. Donado-Godoy Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia npj Antimicrobials and Resistance |
| title | Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia |
| title_full | Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia |
| title_fullStr | Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia |
| title_full_unstemmed | Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia |
| title_short | Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia |
| title_sort | epidemiological genomics of klebsiella pneumoniae isolates from hospitals across colombia |
| url | https://doi.org/10.1038/s44259-025-00127-x |
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