Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast
Pseudoangiomatous stromal hyperplasia (PASH) of the breast is histologically characterized by anastomosing and slit-like spaces invested by collagenous stroma and lined by flattened, spindle cells. These clear spaces that may mimic microscopic vascular channels do not contain red blood cells. Immuno...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2021/7697987 |
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| author | Mohamad Sakibuzzaman Ryan W. Kendziora Toshi Ghosh Malvika H. Solanki Amy Lynn Conners Lisa J. Ahlberg Charles D. Sturgis |
| author_facet | Mohamad Sakibuzzaman Ryan W. Kendziora Toshi Ghosh Malvika H. Solanki Amy Lynn Conners Lisa J. Ahlberg Charles D. Sturgis |
| author_sort | Mohamad Sakibuzzaman |
| collection | DOAJ |
| description | Pseudoangiomatous stromal hyperplasia (PASH) of the breast is histologically characterized by anastomosing and slit-like spaces invested by collagenous stroma and lined by flattened, spindle cells. These clear spaces that may mimic microscopic vascular channels do not contain red blood cells. Immunohistochemistry (IHC) studies may also help to confirm a diagnosis of PASH, with the spindled cells marking positively with CD34 and PR while demonstrating no reactivity with more specific endothelial antigens such as CD31 and ERG. In the current case, a 39-year-old female was diagnosed with cellular PASH of the right breast with unique histological patterns showing “tiger-striped” and “zippered” histologies. To our knowledge, this is the first report of these unique variant PASH morphologies. |
| format | Article |
| id | doaj-art-e47bba9bdd874ba39077d0f925c4cd05 |
| institution | Kabale University |
| issn | 2090-679X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-e47bba9bdd874ba39077d0f925c4cd052025-02-03T01:20:39ZengWileyCase Reports in Pathology2090-679X2021-01-01202110.1155/2021/7697987Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of BreastMohamad Sakibuzzaman0Ryan W. Kendziora1Toshi Ghosh2Malvika H. Solanki3Amy Lynn Conners4Lisa J. Ahlberg5Charles D. Sturgis6Department of Laboratory Medicine and PathologyDepartment of Laboratory Medicine and PathologyDepartment of Laboratory Medicine and PathologyDepartment of Laboratory Medicine and PathologyDepartment of RadiologyDepartment of Internal MedicineDepartment of Laboratory Medicine and PathologyPseudoangiomatous stromal hyperplasia (PASH) of the breast is histologically characterized by anastomosing and slit-like spaces invested by collagenous stroma and lined by flattened, spindle cells. These clear spaces that may mimic microscopic vascular channels do not contain red blood cells. Immunohistochemistry (IHC) studies may also help to confirm a diagnosis of PASH, with the spindled cells marking positively with CD34 and PR while demonstrating no reactivity with more specific endothelial antigens such as CD31 and ERG. In the current case, a 39-year-old female was diagnosed with cellular PASH of the right breast with unique histological patterns showing “tiger-striped” and “zippered” histologies. To our knowledge, this is the first report of these unique variant PASH morphologies.http://dx.doi.org/10.1155/2021/7697987 |
| spellingShingle | Mohamad Sakibuzzaman Ryan W. Kendziora Toshi Ghosh Malvika H. Solanki Amy Lynn Conners Lisa J. Ahlberg Charles D. Sturgis Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast Case Reports in Pathology |
| title | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
| title_full | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
| title_fullStr | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
| title_full_unstemmed | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
| title_short | Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast |
| title_sort | tiger striped pash recognition of a unique morphology allows for a zippered up diagnosis of pseudoangiomatous stromal hyperplasia of breast |
| url | http://dx.doi.org/10.1155/2021/7697987 |
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